Some men with penile cancer have no known risk factors, so it is not possible to completely prevent this disease. The best way to reduce the risk of penile cancer is to avoid known risk factors whenever possible.

Perhaps the most important factor in preventing penile cancer is good genital hygiene. Men should avoid sexual practices likely to result in HPV infection might increase the penile cancer risk.

The longer a person remains infected with any type of HPV that can cause cancer, the greater the risk that infection will lead to cancer. For these reasons, postponing the beginning of sexual activity and limiting the number of sexual partners are two ways to reduce the chances of developing penile cancer.

Smoking, another factor associated with increased penile cancer risk. Quitting smoking or never starting in the first place is an excellent recommendation for preventing many diseases, including penile cancer.