Free Radical Cancer Biology Program
Program Leader: Douglas R. Spitz, , PhD, Associate Professor, Radiation Oncology
The goal of this integrated research program is to
investigate the role of oxidative events, including
peroxidation of cellular membrane lipids, in the therapy of
neoplastic disease. There is convincing evidence that modern
therapy of experimental and human neoplastic disease with
drugs and radiation therapy involves oxidative reactions.
Many of these have free radicals as central mediators. Such
reactions damage membranes, DNA or other cellular
components, either directly or as a result of their
secondary reactions. It seems likely that modulation of
these events can potentiate therapy. The Free Radical Cancer Biology Program focuses on the use of in vitro, ex vivo or small animal systems, including transgenic mice, to test
oxidation based therapeutic approaches to cancer therapy
including chemotherapy, photodynamic and radiation therapy.
Free Radical Cancer Biology Program has two
interactive themes.
- Oxidative events including free radicals and
antioxidant enzymes
- Membrane lipids
Members of the Free Radical Cancer Biology Program
Research Program Membership
Guidelines
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