BS—Simpson College, Indianola, IA
M.A.—Columbia University, New York, NY
PhD—University of Iowa, Iowa City, IA

Honors and Awards

• Service Award, Huntington’s Disease Society of America—2001
• Leadership Award, Huntington’s Disease Society of America—2000
• Giving a Voice to HD Award, Huntington’s Disease Society of America—1999
• Outstanding Young Woman of America—1997
• Alumni Achievement Award, Simpson College—1995
• Young Investigator Award, National Alliance for Research in Schizophrenia and Depression (NARSAD)—1994
• Horansky Award, Huntington’s Disease Society of America—1994
• Dissertation Award, American Psychological Association—1989
• Special Research Scholarship, The University of Iowa—1985-1989
• Research Fellow, Parkinson's Disease Foundation—1985
• Summa cum Laude, BS with honors, Phi Kappa Phi National Honor Society, Simpson College—1983

Professional Activities/Editorial Boards

• American Psychological Association, Div. 40, Clinical Neuropsychology
• International Neuropsychological Society
• National Academy of Neuropsychology
• Huntington Study Group
• American Association for the Advancement of Sciences
• Society for Neuroscience
• Academy of Neurology
• American College of Neuropsychopharmacology
• American Psychological Society
• U.S./Venezuelan Huntington’s Disease Collaborative Research Project

Clinical Interests

• Director, Huntington’s Disease Clinic
• Director, Division of Neuropsychology

Recent Publications

Beglinger LJ, Duff K, Van Der Heiden S, Moser DJ, Bayless JD, Paulsen JS, Gingrich R (2007) Neuropsychological and psychiatric functioning pre- and posthematopoietic stem cell transplantation in adult cancer patients: a preliminary study. J Int Neuropsychol Soc 13:172-177.

Beglinger LJ, Langbehn DR, Duff K, Stierman L, Black DW, Nehl C, Anderson K, Penziner E, Paulsen JS (2007) Probability of obsessive and compulsive symptoms in Huntington's disease. Biol Psychiatry 61:415-418.

Bombard Y, Penziner E, Suchowersky O, Guttman M, Paulsen JS, Bottorff JL, Hayden MR (2007) Engagement with genetic discrimination: concerns and experiences in the context of Huntington disease. Eur J Hum Genet.

Bombard Y, Penziner E, Decolongon J, Klimek ML, Creighton S, Suchowersky O, Guttman M, Paulsen JS, Bottorff JL, Hayden MR (2007) Managing genetic discrimination: strategies used by individuals found to have the Huntington disease mutation. Clin Genet 71:220-231.

Duff K, Paulsen JS, Beglinger LJ, Langbehn DR, Stout JC (2007) Psychiatric Symptoms in Huntington's Disease before Diagnosis: The Predict-HD Study. Biol Psychiatry.

Duff K, Beglinger LJ, Schultz SK, Moser DJ, McCaffrey RJ, Haase RF, Westervelt HJ, Langbehn DR, Paulsen JS (2007) Practice effects in the prediction of long-term cognitive outcome in three patient samples: a novel prognostic index. Arch Clin Neuropsychol 22:15-24.

Feigin A, Tang C, Ma Y, Mattis P, Zgaljardic D, Guttman M, Paulsen JS, Dhawan V, Eidelberg D (2007) Thalamic metabolism and symptom onset in preclinical Huntington's disease. Brain 130:2858-2867.

Hinton SC, Paulsen JS, Hoffmann RG, Reynolds NC, Zimbelman JL, Rao SM (2007) Motor timing variability increases in preclinical Huntington's disease patients as estimated onset of motor symptoms approaches. J Int Neuropsychol Soc 13:539-543.

Hoth KF, Paulsen JS, Moser DJ, Tranel D, Clark LA, Bechara A (2007) Patients with Huntington's disease have impaired awareness of cognitive, emotional, and functional abilities. J Clin Exp Neuropsychol 29:365-376.

Johnson SA, Stout JC, Solomon AC, Langbehn DR, Aylward EH, Cruce CB, Ross CA, Nance M, Kayson E, Julian-Baros E, Hayden MR, Kieburtz K, Guttman M, Oakes D, Shoulson I, Beglinger L, Duff K, Penziner E, Paulsen JS (2007) Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease. Brain 130:1732-1744.

Langbehn DR, Paulsen JS (2007) Predictors of diagnosis in Huntington disease. Neurology 68:1710-1717.

Moser DJ, Robinson RG, Hynes SM, Reese RL, Arndt S, Paulsen JS, Haynes WG (2007) Neuropsychological performance is associated with vascular function in patients with atherosclerotic vascular disease. Arterioscler Thromb Vasc Biol 27:141-146.

Nopoulos P, Magnotta VA, Mikos A, Paulson H, Andreasen NC, Paulsen JS (2007) Morphology of the cerebral cortex in preclinical Huntington's disease. Am J Psychiatry 164:1428-1434.

Penziner E, Williams JK, Erwin C, Bombard Y, Wallis A, Beglinger LJ, Hayden MR, Paulsen JS (2007) Perceptions of discrimination among persons who have undergone predictive testing for Huntington's disease. Am J Med Genet B Neuropsychiatr Genet.

Solomon AC, Stout JC, Johnson SA, Langbehn DR, Aylward EH, Brandt J, Ross CA, Beglinger L, Hayden MR, Kieburtz K, Kayson E, Julian-Baros E, Duff K, Guttman M, Nance M, Oakes D, Shoulson I, Penziner E, Paulsen JS (2007) Verbal episodic memory declines prior to diagnosis in Huntington's disease. Neuropsychologia 45:1767-1776.

Williams JK, Hamilton R, Nehl C, McGonigal-Kenney M, Schutte DL, Sparbel K, Birrer E, Tripp-Reimer T, Friedrich R, Penziner E, Jarmon L, Paulsen J (2007) "No one else sees the difference: "family members' perceptions of changes in persons with preclinical Huntington disease. Am J Med Genet B Neuropsychiatr Genet 144:636-641.

Zimbelman JL, Paulsen JS, Mikos A, Reynolds NC, Hoffmann RG, Rao SM (2007) fMRI detection of early neural dysfunction in preclinical Huntington's disease. J Int Neuropsychol Soc 13:758-769.

Feigin, A., Ghilardi, M. F., Huang, C., Ma, Y., Carbon, M., Guttman, M., Paulsen, J. S., Ghez, C. P. & Eidelberg, D. (2006). Preclinical Huntington's disease: compensatory brain responses during learning. Ann Neurol59, 53-9.

Li, J. L., Hayden, M. R., Warby, S. C., Durr, A., Morrison, P. J., Nance, M., Ross, C. A., Margolis, R. L., Rosenblatt, A., Squitieri, F., Frati, L., Gomez-Tortosa, E., Garcia, C. A., Suchowersky, O., Klimek, M. L., Trent, R. J., McCusker, E., Novelletto, A., Frontali, M., Paulsen, J. S., Jones, R., Ashizawa, T., Lazzarini, A., Wheeler, V. C., Prakash, R., Xu, G., Djousse, L., Mysore, J. S., Gillis, T., Hakky, M., Cupples, L. A., Saint-Hilaire, M. H., Cha, J. H., Hersch, S. M., Penney, J. B., Harrison, M. B., Perlman, S. L., Zanko, A., Abramson, R. K., Lechich, A. J., Duckett, A., Marder, K., Conneally, P. M., Gusella, J. F., MacDonald, M. E. & Myers, R. H. (2006). Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC Med Genet7, 71.

Moser, D. J., Robinson, R. G., Hynes, S. M., Reese, R. L., Arndt, S., Paulsen, J. S. & Haynes, W. G. (2006). Neuropsychological Performance Is Associated With Vascular Function in Patients With Atherosclerotic Vascular Disease, pp. 01.ATV.0000250973.93401.2d.

Paulsen, J. S., Hayden, M., Stout, J. C., Langbehn, D. R., Aylward, E., Ross, C. A., Guttman, M., Nance, M., Kieburtz, K., Oakes, D., Shoulson, I., Kayson, E., Johnson, S. & Penziner, E. (2006a). Preparing for preventive clinical trials: the Predict-HD study. Arch Neurol63, 883-90.

Paulsen, J. S., Hayden, M., Stout, J. C., Langbehn, D. R., Aylward, E., Ross, C. A., Guttman, M., Nance, M., Kieburtz, K., Oakes, D., Shoulson, I., Kayson, E., Johnson, S., Penziner, E. & and the Predict, H. D. I. o. t. H. S. G. (2006b). Preparing for Preventive Clinical Trials: The Predict-HD Study, vol. 63, pp. 883-890.

Paulsen, J. S., Magnotta, V. A., Mikos, A. E., Paulson, H. L., Penziner, E., Andreasen, N. C. & Nopoulos, P. C. (2006c). Brain structure in preclinical Huntington's disease. Biol Psychiatry59, 57-63.

Beglinger, L. J., Nopoulos, P. C., Jorge, R. E., Langbehn, D. R., Mikos, A. E., Moser, D. J., Duff, K., Robinson, R. G. & Paulsen, J. S. (2005). White Matter Volume and Cognitive Dysfunction in Early Huntington's Disease. Cognitive and Behavioral Neurology18, 102-107.

Paulsen J, Ferneyhough K, Nehl C, Stierman BS, and the Huntington Study Group (2005).  Critical periods of suicide risk in Huntington's disease.  American Journal of Psychiatry, 162:4, 725-731.

Duff, K., Schoenberg, M. R., Patton, D., Paulsen, J. S., Bayless, J. D., Mold, J., Scott, J. G. & Adams, R. L. (2005). Regression-based formulas for predicting change in RBANS subtests with older adults. Archives of Clinical Neuropsychology20, 281-290.

Paulsen, J. S. & Conybeare, R. A. (2005). Cognitive changes in Huntington's disease. Adv Neurol96, 209-25.

Paulsen, J. S., Hoth, K. F., Nehl, C. & Stierman, L. (2005a). Critical periods of suicide risk in Huntington's disease. Am J Psychiatry162, 725-31.

Paulsen, J. S., Nehl, C., Hoth, K. F., Kanz, J. E., Benjamin, M., Conybeare, R., McDowell, B. & Turner, B. (2005b). Depression and stages of Huntington's disease. J Neuropsychiatry Clin Neurosci17, 496-502.

Djousse, L., Knowlton, B., Hayden, M. R., Almqvist, E. W., Brinkman, R. R., Ross, C. A., Margolis, R. L., Rosenblatt, A., Durr, A., Dode, C., Morrison, P. J., Novelletto, A., Frontali, M., Trent, R. J., McCusker, E., Gomez-Tortosa, E., Mayo Cabrero, D., Jones, R., Zanko, A., Nance, M., Abramson, R. K., Suchowersky, O., Paulsen, J. S., Harrison, M. B., Yang, Q., Cupples, L. A., Mysore, J., Gusella, J. F., MacDonald, M. E. & Myers, R. H. (2004). Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16. Neurogenetics5, 109-14.

Moser DJ, Hoth KF, Robinson RG, Paulsen JS, Sinkey CA, Benjamine ML, Schultz SK, Haynes WG (2004).  Blood vessel function and cognition in elderly patients with atherosclerosis.  Stroke 35:e369-e372.

Fennema-Notestine, C., Archibald, S. L., Jacobson, M. W., Corey-Bloom, J., Paulsen, J. S., Peavy, G. M., Gamst, A. C., Hamilton, J. M., Salmon, D. P. & Jernigan, T. L. (2004). In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease. Neurology63, 989-95.

Langbehn, D. R., Brinkman, R. R., Falush, D., Paulsen, J. S. & Hayden, M. R. (2004). A new model for prediction of the age of onset and penetrance for Huntington's disease based on CAG length. Clin Genet65, 267-77.

McDowell, B. D., Bayless, J. D., Moser, D. J., Meyers, J. E. & Paulsen, J. S. (2004). Concordance between the CVLT and the WMS-III word lists test. Archives of Clinical Neuropsychology19, 319-324.

Moser, D. J., Arndt, S., Kanz, J. E., Benjamin, M. L., Bayless, J. D., Reese, R. L., Paulsen, J. S. & Flaum, M. A. (2004). Coercion and Informed Consent in Research Involving Prisoners. Comprehensive Psychiatry45, 1-9.

Nehl, C. & Paulsen, J. S. (2004). Cognitive and psychiatric aspects of Huntington disease contribute to functional capacity. J Nerv Ment Dis192, 72-4.

Paulsen, J. S., Zimbelman, J. L., Hinton, S. C., Langbehn, D. R., Leveroni, C. L., Benjamin, M. L., Reynolds, N. C. & Rao, S. M. (2004). fMRI biomarker of early neuronal dysfunction in presymptomatic Huntington's Disease. AJNR Am J Neuroradiol25, 1715-21.

Sadek, J. R., Johnson, S. A., White, D. A., Salmon, D. P., Taylor, K. I., Delapena, J. H., Paulsen, J. S., Heaton, R. K. & Grant, I. (2004). Retrograde amnesia in dementia: comparison of HIV-associated dementia, Alzheimer's disease, and Huntington's disease. Neuropsychology18, 692-9.

Wexler, N. S., Lorimer, J., Porter, J., Gomez, F., Moskowitz, C., Shackell, E., Marder, K., Penchaszadeh, G., Roberts, S. A., Gayan, J., Brocklebank, D., Cherny, S. S., Cardon, L. R., Gray, J., Dlouhy, S. R., Wiktorski, S., Hodes, M. E., Conneally, P. M., Penney, J. B., Gusella, J., Cha, J. H., Irizarry, M., Rosas, D., Hersch, S., Hollingsworth, Z., MacDonald, M., Young, A. B., Andresen, J. M., Housman, D. E., De Young, M. M., Bonilla, E., Stillings, T., Negrette, A., Snodgrass, S. R., Martinez-Jaurrieta, M. D., Ramos-Arroyo, M. A., Bickham, J., Ramos, J. S., Marshall, F., Shoulson, I., Rey, G. J., Feigin, A., Arnheim, N., Acevedo-Cruz, A., Acosta, L., Alvir, J., Fischbeck, K., Thompson, L. M., Young, A., Dure, L., O'Brien, C. J., Paulsen, J., Brickman, A., Krch, D., Peery, S., Hogarth, P., Higgins, D. S., Jr. & Landwehrmeyer, B. (2004). Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A101, 3498-503.

Djousse, L., Knowlton, B., Hayden, M., Almqvist, E. W., Brinkman, R., Ross, C., Margolis, R., Rosenblatt, A., Durr, A., Dode, C., Morrison, P. J., Novelletto, A., Frontali, M., Trent, R. J., McCusker, E., Gomez-Tortosa, E., Mayo, D., Jones, R., Zanko, A., Nance, M., Abramson, R., Suchowersky, O., Paulsen, J., Harrison, M., Yang, Q., Cupples, L. A., Gusella, J. F., MacDonald, M. E. & Myers, R. H. (2003). Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease. Am J Med Genet A119, 279-82.

Hamilton, J. M., Salmon, D. P., Corey-Bloom, J., Gamst, A., Paulsen, J. S., Jerkins, S., Jacobson, M. W. & Peavy, G. (2003). Behavioural abnormalities contribute to functional decline in Huntington's disease. J Neurol Neurosurg Psychiatry74, 120-2.

Li, J. L., Hayden, M. R., Almqvist, E. W., Brinkman, R. R., Durr, A., Dode, C., Morrison, P. J., Suchowersky, O., Ross, C. A., Margolis, R. L., Rosenblatt, A., Gomez-Tortosa, E., Cabrero, D. M., Novelletto, A., Frontali, M., Nance, M., Trent, R. J., McCusker, E., Jones, R., Paulsen, J. S., Harrison, M., Zanko, A., Abramson, R. K., Russ, A. L., Knowlton, B., Djousse, L., Mysore, J. S., Tariot, S., Gusella, M. F., Wheeler, V. C., Atwood, L. D., Cupples, L. A., Saint-Hilaire, M., Cha, J. H., Hersch, S. M., Koroshetz, W. J., Gusella, J. F., MacDonald, M. E. & Myers, R. H. (2003). A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study. Am J Hum Genet73, 682-7.

Hamilton JM, Salmon DP, Corey-Bloom J, Gamst A, Paulsen JS, Jerkins S, Jacobson MW, Peavy G. (2003). Behavioural abnormalities contribute to functional decline in Huntington's disease, Journal of Neurology, Neurosurgery, and Psychiatry 74; 120-122.M.

Moser DJ, Schultz SK, Arndt, S, Benjamin ML, Fleming FW, Brems CS, Paulsen JS, Appelbaum PS, Andreasen NC (2002). Capacity to provide informed consent for participation in schizophrenia and HIV research. Am J Psychiatry 159:1201-1207.

Peavy GM, Salmon DP, Bear I, Paulsen JS, Cahn DA, Hofstetter CR, Kaplan EF, Delis DC, Shults CW. Detection of mild cognitive deficits in Parkinson’s disease patients with the WAIS-R NI. JINS (2001). 7(5): 535-543.

Paulsen JS, Ready RE, Hamilton JM, Mega MS, Cummings, JL Neuropsychiatric aspects of Huntington’s disease. Journal of Neurology, Neurosurgery & Psychiatry (2001). 71:310-314.

The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q₁₀ and remacemide in Huntington’s disease. Neurology (2001). 57:397-404.

Paulsen JS, Ross C, Brinkman R, Stout JC & the Huntington Study Group. Clinical markers of early disease in persons near onset of Huntington’s disease. Neurology (2001). 57:658-662.

Nehl C, Ready RE, Hamilton J, & Paulsen JS. The effects of depression on working memory in pre-symptomatic Huntington’s Disease. J Neuropsychiatry Clin Neurosci (2001). 13:342-346.

Ready RE, Stierman L, & Paulsen JS. Ecological validity of Neuropsychological and personality measures of executive functions (2001). The Clinical Neuropsychologist, 15(3):314-323.

Kuperman S, Perry PJ, Gaffney GR, Lund BC, Bever-Stille A, Arndt S, Holman T, Moser DJ, Paulsen JS. (2001). Bupropion SR vs. Methylphenidate vs. Placebo for Attention Deficit Hyperactivity Disorder in Adults. Annals of Clinical Psychiatry, 13(3):129-134.

Moser DJ, Cohen RA, Paul R, Paulsen JS, Ott B, Gordon N, Bell S, & Stone WM (2001).

Executive function and MRI subcortical hyperintensities in vascular dementia. Neuropsychiatry, Neuropsychology & Behavioral Neurology, 4(2):89-92.

Kulisevsky J, Litvan I, Berthier ML, Pascual-Sedano B, Paulsen JS, Cummings JL.

Neuropsychiatric Assessment of Gilles de la Tourette Patients: Comparative Study with Other Hyperkinetic and Hypokinetic Movement Disorders. (2001). Movement Disorders, 16: 1098-1104.

Paulsen JS, Ross C, Brinkman R, Stout JC & the Huntington Study Group. (2001).

Clinical markers of early disease in persons near onset of Huntington’s disease. Neurology, 57:658-662.

Paulsen JS, Salmon DP, Thal LJ, Romero R, Weisstein-Jenkins C, Galasko D, Hofstetter CR, Thomas R, Grant I & Jeste DV (2000). Incidence of and risk factors for hallucinations and delusions in patients with probable AD. Neurology, 54(10):1965-1971.

Paulsen JS, Ready RE, Stout JC, Salmon DP, Thal LJ, Grant I & Jeste DV (2000).

Neurobehaviors and psychotic symptoms in Alzheimer's disease. JINS, 6: 815-820.

Arroyos-Jurado E, Paulsen JS, Merrell KW, Lindgren S & Max JE (2000). Traumatic brain injury in school-age children: academic and social outcomes. Journal of School Psychology, 38(6):571-587.

Burin D, Paulsen JS, Jorge R & Arizaga R (2000). Estimation of premorbid intelligence: the Word Accentuation Test - Buenos Aires version. J Clin Exp Neuropsychol, 22(5):677-685.

Marder K, Zhao H, Myers RH, Cudkowicz M, Kayson E, Kieburtz K, Orme C, Paulsen JS, Penney J, Jr., Siemers E, Shoulson I & The Huntington Study Group (2000). Rate of functional decline in Huntington's disease. Neurology, 54(2):452-458.

Paulsen, JS (1999). Understanding Behavior in Huntington Disease. Cambridge, ON, Huntington Society of Canada.

Evans JD, Negron AE, Palmer BW, Paulsen JS, Heaton RK & Jeste, DV (1999).

Cognitive deficits and psychopathology in institutionalized versus community-dwelling elderly schizophrenia patients. J Geriatr Psychiatry Neuro, 12(1):11-15.

Mohamed S, Paulsen JS, O'Leary D, Arndt S & Andreasen NC (1999). Generalized cognitive deficits in schizophrenia: a study of first-episode patients. Arch Gen Psychiatry, 56(8):749-754.

Moore AB, Paulsen JS & Murphy C (1999). A test of odor fluency in patients with Alzheimer's and Huntington's disease. J Clin Exp Neuropsychol, 21(3):341-351.

Rohrer D, Salmon DP, Wixted JT & Paulsen JS (1999). The disparate effects of Alzheimer's disease and Huntington's disease on semantic memory. Neuropsychology, 13(3):381-388.

Hamilton JM, Murphy C & Paulsen JS (1999). Olfactory learning and memory in Huntington's disease. JINS, 5(7):609-615.

Evans JD, Heaton RK, Paulsen JS, McAdams LA, Heaton SC & Jeste DV (1999).

Schizoaffective disorder: a form of schizophrenia or affective disorder? Journal of Clinical Psychiatry, 60(12):874-882.

Marder K, Zhao H, Myers RH, Cukowicz M, Kayson E, Kieburtz K, Orme C, Paulsen J, Penney JB, Siemers E, Shoulson I, Huntington Study Group (1999). Rate of functional decline in Huntington’s disease. Neurology, 54:452-458.

Address

Office location: 1-305 MEB
Phone: 319-353-4551
Fax: 319-353-3003
E-mail: jane-paulsen@uiowa.edu