Research Scientist, Director of Research
gerene-denning@uiowa.edu

Research Interests

Basic and translational research in hibernation, delta opioids, myocardial ischemia, inflammation, and exercise.

Professional Affiliations

• Women in Science and Engineering Program (WISE), Associate Director
• Society of Academic Emergency Medicine (SAEM), Member of Research Directors' Interest Group
• American Physiological Society (APS)

Selected Peer-reviewed Publications (10 of 54)

1. Denning, GM , Railsback, MA, Rasmussen, GT, Cox, CD, and Britigan, BE Pseudomonas Pyocyanine Alters Calcium Signaling in Human Airway Epithelial Cells. Am. J. Physiol. 274 :L893-L900, 1998
2. Denning, GM , Wollenweber, LA, Railsback, MA, Cox, CD, Stoll, LL, and Britigan, BE Pseudomonas Pyocyanin Increases Interleukin-8 Release by Human Airway Epithelial Cells. Infect. Immun . 66 :5777-5784, 1998.
3. Leidal, KG, Munson, K, Johnson, M, and Denning, GM . Small molecular weight factors from Pseudomonas aeruginosa have opposite effects on IL-8 and RANTES release by human airway epithelial cells. Am. J. Respir. Cell Mol. Biol . 25 :186-195, 2001.
4. Leidal, KG, Munson, KL, Johnson, M, and Denning, GM . Metalloproteases from Pseudomonas aeruginosa -degrade human RANTES, MCP-1 and ENA-78. J. Interfer. Cyt. Res. 23:307-318, 2003.
5. Stoll, LL, McCormick, ML, Denning, GM, Weintraub, NL. Antioxidant effects of statins. Timely Top Med Cardiovasc Dis . 9:E1, 2005.
6. Denning, GM and Stoll, LL. Peroxisome proliferator-activated receptors: Potential therapeutic targets in lung disease (Review). Pediatric Pulmonology , 41:23-34, 2006.
7. Dickson, EW, Ludwig, PS, Ackermann, LW, Buresh, CT and Denning, GM . Met-enkephalin-Arg-Phe (MEAP): A cardioprotective hormonal opioid. Acad. Emerg. Med. 18:813-819, 2006.
8. Stoll, LL, Denning, GM and Weintraub, NL. Endotoxin, TLR4 signaling and vascular inflammation: Potential therapeutic targets in cardiovascular disease (Review). Current Pharmaceutical Design , 12(32):4229-4245, 2006.
9. Dickson, EW, Hogrefe, CP, Ludwig, PS, Ackermann, LW, Stoll, LL, Denning, GM . Exercise Enhances Myocardial Ischemic Tolerance via an Opioid Receptor-Dependent Mechanism, Am J Physiol Heart Circ Physiol . 294:H402-H408, 2008.
10. Denning, GM , Ackermann, LW, Barna, TJ, Armstrong, JG, Stoll, LL, Weintraub, NL, and Dickson, EW. Proenkephalin expression and enkephalin release are widely observed in non-neuronal tissues. Peptides 29:83-92, 2008.
11. Brett Faine, PharmD, Mark Nunge, MD, Gerene Denning, PhD, Andrew Nugent, MD. Implementing Evidence-Based Changes in Emergency Department Treatment: Alternative Vitamin Therapy for Alcohol-Related Illnesses. Ann. Em. Med. Online. 2011.
12. Denning, GM, Jennissen, CA, Ellis, DG, and CT Buresh. Creating a Statewide ATV Injury Surveillance Database: Strategies and Implementation. Journal of Injury Prevention, Submitted.

Abstracts (Injury Prevention and Clinical Science)

1. Gerene M. Denning, David G. Ellis, Corinne Peek-Asa, Tracy L. Young, David A. Katz, Charles A. Jennissen, and Christopher T. Buresh. Integration of three major Iowa databases provides statewide analysis of ATV-related crashes and injuries. Great Plains Society of Academic Emergency Medicine, Omaha, September 17-18, 2010.
2. David G. Ellis, Gerene M. Denning, and Christopher T. Buresh. Integration of three major Iowa databases provides statewide analysis of ATV-related crashes and injuries. Interdisciplinary Health Group Research Day, Iowa City, 2010.
3. M.E. Takacs, L.R.M. Thompson, K. Dostal, G. Denning, and A. Nugent. The 21-only ordinance reduced alcohol-related adverse consequences among college age students. Annual meeting of the Society for Academic Emergency Medicine (SAEM). Boston, June 1-5, 2011.
4. C.A. Jennissen, G. Denning, and E. Wolfe. The safety information and guidance provided to parents by all-terrain vehicle dealers and sales representatives. Annual meeting of the Society for Academic Emergency Medicine (SAEM). Boston, June 1-5, 2011.
5. B.A. Faine, G.R. Bell, and G.M Denning. A comparison of the efficacy of 3-day, twice daily nitrofurantoin (Macrobid) versus 3-day, twice daily ciprofloxacin in females with uncomplicated bacterial cystitis. Annual meeting of the Society for Academic Emergency Medicine (SAEM). Boston, June 1-5, 2011.