Residency
(Neurology) University of Iowa Hospitals and Clinics, Iowa City, IA
(Internship) Saint Vincent Hospital, Worcester, MA

Fellowship
Movement Disorders, University of Iowa Hospitals and Clinics, Iowa City, IA

Honors and Awards

• 1996: Introduction to Research Scholarship (CSIC-Superior Council for Research, Spain)
• 2001-2002: Co-Chief Resident. Department of Neurology. University of Hospitals and Clinics, Iowa City, IA
• 2002-2004: Menkes/Markham Fellow (Dystonia Medical Research Foundation)
• 2003: S. Weir Mitchell Award (American Academy of Neurology)
• 2004: Junior Award for Excellence in Basic Science Research, 8th International Congress of Parkinson's Disease and Movement Disorders, Rome (Italy)

Professional Affiliations

• American Academy of Neurology
• Movement Disorder Society
• Society for Neurosciences

Professional Activities/Editorial Boards

• 2006-present: Member, Scientific Advisory Board, Spastic Paraplegia Foundation
• 2006-present: Member, Medical and Scientific Advisory Council, Dystonia Medical Research Foundation
• Ad Hoc Reviewer:
  • Human Molecular Genetics
  • Cellular and Molecular Neurobiology
  • The Journal of the Neurological Sciences
  • Journal of Gene Medicine
  • Journal of Neuroscience
  • Annals of Otology, Rhinology and Laryngology
  • Neurology
  • Emergency Medicine Journal
  • European Journal of Neuroscience
  • Life Sciences

Clinical Interests

• Movement disorders
• Inherited dystonias
• Neurogenetic disorders

Research Interests

• Biological basis of basal ganglia diseases, especially dystonia.
• Molecular basis of neurodegeneration
• Role of AAA proteins in neurological disease

Publications

Sanchez-Chaparro MA, Merida de la Torre FJ, Gonzalez-Alegre P, Gonzalez-Santos P. Transverse myelitis caused by Brucella. Rev Clin Esp 1999 Nov;199(11):778.

Gonzalez-Alegre P, Ruiz-Lopez AD, Abarca-Costalago M, Gonzalez-Santos P. Increment of the platelet count in temporal arteritis: response to therapy and ischemic complications. Eur Neurol 2001;45(1):43-45.

Bonansco C, González de la Vega A , González-Alegre P, Borde M, García-Segura LM and Buño W. Tetanic stimulation of Schaffer collaterals induces rhythmic bursts via NMDA receptor activation in rat CA1 pyramidal neurons. Hippocampus 2002;12:434-446.

Gonzalez-Alegre P, Recober A, Kelkar P. Idiopathic Brachial Neuritis. Iowa Orthop J 2002; 22:81-85.

Gonzalez-Alegre P, Tippin J. Prolonged cortical electrical depression and diffuse vasospasm without ischemia in a case of severe hemiplegic migraine during pregnancy. Headache 2003;43:72-75.

Gonzalez-Alegre P, Miller VM, Davidson B, Paulson H. Toward therapy for DYT1 dystonia: Allele-specific silencing of mutant torsinA. Annals of Neurology 2003;53:781-787.

Gonzalez-Alegre P, Ammache Z, Davis PH, Rodnitzky R. Moyamoya-induced paroxysmal dyskinesia. Mov Disord 2003;18(9):1051-1056.

Gonzalez-Alegre P, Paulson HP. Aberrant cellular behavior of mutant TorsinA implicates nuclear envelope dysfunction in DYT1 dystonia. J Neurosci 2004;24(11):2593-2601.

Gonzalez-Alegre P. Severe interscapular pain and elevated creatine kinase: the answer was in the ankles. Emerg Med J 2005;22:148-155.

Gonzalez-Alegre P, Bode N, Davidson BL, Paulson HP. Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1. J Neurosc 2005;25: 10502-10509.

Gonzalez-Alegre P, Afifi AK. Clinical Characteristics of Childhood - Onset (Juvenile) Huntington's Disease. Report of Twelve Patients and Review of the Literature. Journal of Child Neurology 2006;21(3):223-229.

Jinnah HA, Visser JE, Harris JC, Verdu A, Larovere L, Ceballos-Picot I, Gonzalez-Alegre P, Neychev V, Torres RJ, Dulac O, Desguerre I, Schretlen DJ, Robey KJ, Barabas G, Bloem BR, Nyhan W, Kremer R, Eddey GE, Puig JG, Reich SG. Delineation of the Motor Disorder of Lesch-Nyhan Disease. Brain 2006;129:1201-17.

Gonzalez-Alegre P, Kelkar P, Rodnitzky RL. Isolated high frequency jaw tremor relieved by botulinum toxin injections. Mov Disord 2006;21(7):1049-50.

Gonzalez-Alegre P. Monomelic Parkinsoniam Tremor Caused by Contralateral Substantia Nigra Stroke. Parkinsonism Relat Disord. 2007;13(3):182-184.

Miller VM, Paulson HL, Gonzalez-Alegre P. RNA interference in neuroscience: progress and challenges. Cellular and Molecular Neurobiology 2005;25(8):1195-1207.

Rodriguez-Lebron E, Gonzalez-Alegre P. Silencing neurodegenerative disease: bringing RNAi to the clinic. Expert Review of Neurotherapeutics 2006;6(2):223-233.

Gonzalez-Alegre P. Therapeutic RNA interference for neurodegenerative diseases: from promise to progress. Pharmacology & Therapeutics 2007;114(1):34-55.

Gonzalez-Alegre P and Paulson HL. Therapeutic RNA interference-how far from the neurology clinic? Nat Clin Pract Neurol In press.

Paulson H, Gonzalez-Alegre P. RNAi gets its prize. Lancet Neurol 2006;5(12):997-999.

Gonzalez-Alegre P. The Inherited Dystonias. Sem Neurol. 2007;27(2):151-158.

Harper SQ and Gonzalez-Alegre P. Lentiviral-mediated RNA interference in mammalian neurons. In: Methods in Molecular Biology: RNA interference. Edited by: S. Barik. The Humana Press Inc., Totowa, NJ. In press.