Medical School
MD University of Santo Tomas, Manila, Philippines
PhD (Biochemistry) University of Pennsylvania
Internship, State University of New York Downstate Medical Center
Residency
Residency in Neurology, University of Chicago
Fellowship
Honors and Awards
Professional Activities / Editorial Boards
Editorial board, International Journal of Developmental
Neuroscience, 1984-1991
Editorial board, Neurochemical Reserch, 1998-2005
Editorial board, Handbook Neurochem & Mol Neurobiology, 2005
International Society for Neurochemistry Visiting Lectureship, 1986
Professional Affiliations
- American Society for Neurochemistry
- International Society for Neurochemistry
- Society for Neuroscience
- American Society for Biochemistry & Molecular Biology
- American Society for Cell Biology
- International Society for Developmental Neuroscience
- American Academy of Neurology
Clinical Interests
Specialty: Neurochemistry and Neurobiology
General neurology with emphasis in neurogerontology
Research Interests
- Biochemistry and molecular biology of brain cells
- Development and regeneration of brain cells
- Growth factors and signal transduction
- Mechanism and control of brain tumors
- Detection of molecular alterations in Alzheimer brains
- Role of GMF in signal transduction
- Role of GMF in neuroimmunology
Recent Publications / Reviews
A. Zaheer and R. Lim: Overexpression of glia maturation factor
(GMF) in PC12 pheochromocytoma cells activates p38 MAP kinase, MAPKAP
kinase-2, and tyrosine hydroxylase, Biochem. Biophys. Res.
Comm., 250, 278-282 (1998).
A. Zaheer, J. L. Weiss, P. Goyal and R. Lim: Enhanced expression
of neurotrophic factors by C6 cells after transfection with glia
maturation factor (GMF), Neurosci. Lett., 265, 203-206 (1999).
R. Lim, A. Zaheer, M.A. Yorek, C.J. Darby and L.W. Oberley:
Activation of NF-kB in C6 rat glioma cells after transfection with
glia maturation factor (GMF), J. Neurochem., 74, 596-602 (2000).
N.J. Pantazis, A. Zaheer, D. Dai, S. Zaheer, S.H., Green and R.
Lim: Transfection of C6 glioma cells with glia maturation factor
upregulates BDNF and NGF : trophic effects and protection against
ethanol toxicity in cerebellar granule cells, Brain Res., 865, 59-76 (2000).
A. Zaheer, M.A. Yorek and R. Lim: Effects of glia maturation factor
overexpression in primary astrocytes on MAP kinase activation, transcription
factor activation, and neurotrophin secretion, Neurochem. Res., 26,
1293-1299 (2001).
A. Zaheer, S.N. Mathur and R. Lim: Overexpression of glia maturation factor
in astrocytes leads to immune activation of microglia through secretion of
granulocyte-macrophage-colony stimulating factor, Biochem. Biophys. Res.
Comm., 294, 238-244 (2002).
A.Zaheer, B. Yang, X. Cao and R. Lim: Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes, Neurochem. Res., 29, 1473-1480 (2004).
R. Lim, A. Zaheer, H. Khosravi, J.H. Freeman Jr., H.E. Halverson, J.A. Wemmie, and B. Yang: Impaired motor performance and learning in glia maturation factor-knockout mice, Brain Res., 1024, 225-232 (2004).
R. Lim and A. Zaheer: Glia Maturation Factor in Brain Function, in Handbook of Neurochemistry and Molecular Neurobiology, 3rd edition (A. Lajtha, chief Ed.), Vol. 9, Neuroactive Proteins and Peptides (R. Lim, vol. Ed), Springer, 2006.
A. Zazeer, J.T.Haas, C. Reyes, S.N. Mathur, B. Yang and R. Lim: GMF-Knockout mice are unable to induce brain-derived neurotrophic factor after exercise, Neurochem. Res., 31, 579-584 (2006).
A. Zaheer, S. Zaheer, S. Sahu, B. Yang and R. Lim: Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice, Neurochem. Res., 32, 39-47 (2007).
Address
Office location: 251 EMRB
Phone: 319-335-8527
Fax: 319-335-8528
E-mail: ramon-lim@uiowa.edu
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