Ramon Lim, MD, PhD
Emeritus Professor of Neurology
Address
Office location: 251 EMRB
Phone: 319-335-8527
Fax: 319-335-8528
E-mail: ramon-lim@uiowa.edu
Clinical Specialty
General neurology with emphasis in neurogerontology
Research Interests
- Neurochemistry and Neurobiology
- Biochemistry and molecular biology of brain cells
- Development and regeneration of brain cells
- Growth factors and signal transduction
- Mechanism and control of brain tumors
- Detection of molecular alterations in Alzheimer brains
- Role of GMF in signal transduction
- Role of GMF in neuroimmunology
Education
MD University of Santo Tomas, Manila, Philippines
PhD (Biochemistry) University of Pennsylvania
Residency
Internship, State University of New York Downstate Medical Center
Residency in Neurology, University of Chicago
Fellowship
Neurochemistry research, University of Michigan
Special fellow, National Institute of Mental Health
Certification
Iowa State license
American Board of Psychiatry and Neurology
Honors and Awards
- M.D. cum laude, University of Santo Tomas, Manila, Philippines, 1958
- Outstanding Overseas Chinese, Federation of Overseas Chinese Association, Taipei, Taiwan, 1961
- Am. Men & Women of Science, l969-
- Career Investigator Award, Veterans Administration, 1983-1986
- International Society for Neurochemistry Visiting Lectureship, 1986
- Who's Who in Science & Engineering, 1992-
- Who's Who in the World, 1993-
- Who's Who in America, 2000-
- Distinguished alumnus, 2008, University of Santo Tomas
Grants
Numerous grants from NIH, NSF and Veterans Administration
Professional Service
- Editorial board, International Journal of Developmental Neuroscience, 1984-1991
- Editorial board, Neurochemical Reserch, 1998-2005
- Editorial board, Handbook Neurochem & Mol Neurobiology, 2005
Professional Affiliations
- American Society for Neurochemistry
- International Society for Neurochemistry
- Society for Neuroscience
- American Society for Biochemistry & Molecular Biology
- American Society for Cell Biology
- International Society for Developmental Neuroscience
- American Academy of Neurology
Lectures
Harvard University; Yale University; Columbia University; University of Chicago; Pasteur Institute (France); Beijing University (China); Peking Union Medical University (China)
Publications
A. Zaheer and R. Lim: Overexpression of glia maturation factor (GMF) in PC12 pheochromocytoma cells activates p38 MAP kinase, MAPKAP kinase-2, and tyrosine hydroxylase, Biochem. Biophys. Res. Comm., 250, 278-282 (1998).
A. Zaheer, J. L. Weiss, P. Goyal and R. Lim: Enhanced expression of neurotrophic factors by C6 cells after transfection with glia maturation factor (GMF), Neurosci. Lett., 265, 203-206 (1999).
R. Lim, A. Zaheer, M.A. Yorek, C.J. Darby and L.W. Oberley: Activation of NF-kB in C6 rat glioma cells after transfection with glia maturation factor (GMF), J. Neurochem., 74, 596-602 (2000).
N.J. Pantazis, A. Zaheer, D. Dai, S. Zaheer, S.H., Green and R. Lim: Transfection of C6 glioma cells with glia maturation factor upregulates BDNF and NGF : trophic effects and protection against ethanol toxicity in cerebellar granule cells, Brain Res., 865, 59-76 (2000).
A. Zaheer, M.A. Yorek and R. Lim: Effects of glia maturation factor overexpression in primary astrocytes on MAP kinase activation, transcription factor activation, and neurotrophin secretion, Neurochem. Res., 26, 1293-1299 (2001).
A. Zaheer, S.N. Mathur and R. Lim: Overexpression of glia maturation factor in astrocytes leads to immune activation of microglia through secretion of granulocyte-macrophage-colony stimulating factor, Biochem. Biophys. Res. Comm., 294, 238-244 (2002).
A.Zaheer, B. Yang, X. Cao and R. Lim: Decreased copper-zinc superoxide dismutase activity and increased resistance to oxidative stress in glia maturation factor-null astrocytes, Neurochem. Res., 29, 1473-1480 (2004).
R. Lim, A. Zaheer, H. Khosravi, J.H. Freeman Jr., H.E. Halverson, J.A. Wemmie, and B. Yang: Impaired motor performance and learning in glia maturation factor-knockout mice, Brain Res., 1024, 225-232 (2004).
R. Lim and A. Zaheer: Glia Maturation Factor in Brain Function, in Handbook of Neurochemistry and Molecular Neurobiology, 3rd edition (A. Lajtha, chief Ed.), Vol. 9, Neuroactive Proteins and Peptides (R. Lim, vol. Ed), Springer, 2006.
A. Zazeer, J.T.Haas, C. Reyes, S.N. Mathur, B. Yang and R. Lim: GMF-Knockout mice are unable to induce brain-derived neurotrophic factor after exercise, Neurochem. Res., 31, 579-584 (2006).
A. Zaheer, S. Zaheer, S. Sahu, B. Yang and R. Lim: Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice, Neurochem. Res., 32, 39-47 (2007).
A. Zaheer, S. Zaheer, S. Sahu, S. knight, H. Khosravi, S. N. Mathur and R. Lim: A novel role of glia maturation factor: induction of granulocyte-macrophage colony-stimulating factor and pro-inflammatory cytokines, J. Neurochem., Jan. 22, 2007.