Residency
(Residency) University of Pennsylvania Medical School, Philadelphia, PA
(Internship) Robert Wood Johnson Hospital, New Brunswick, NJ

Fellowship
Movement Disorders and Neurogenetics, University of Pennsylvania Medical Center and Graduate Hospital, Philadelphia, PA

Honors and Awards

• 1983-1990 Medical Scientist Training Program Fellowship, NIH
• 1991 "Best Intern," Robert Wood Johnson Hospital, University of Medicine and Dentistry, New Brunswick, NJ.
• 1993 Samuel Zeritsky Prize, awarded for outstanding research by a neurology resident at the University of Pennsylvania.
• 1994 Research Fellowship Award, Hereditary Disease Foundation
• 1994-1998 Research Fellowship Award, American Academy of Neurology
• 1994-1997 Postdoctoral Research Fellowship, Howard Hughes Medical Institute
• 1999-2003 New Scholars Award, Ellison Medical Foundation
• 2001-2001 Semi-finalist, W. M. Keck Foundation Young Scholars in Medical Research Program
• 2003-2006 Paul Beeson Physician Faculty Scholar in Aging, American Federation for Aging Research

Professional Activities/ Editorial Boards

• Steering Committee for Coalition for the Cure, Huntington Disease Society of America
• Medical and Scientific Advisory Committee, Huntington Disease Society of America
• Medical and Research Advisory Board, National Ataxia Foundation
• Clinical Therapeutics Committee, Coordinated Ataxia Group
• Scientific Advisory Board, Ataxia MJD Research Project
• Annual Meeting Subcommittee of American Academy of Neurology
• Director, Genetics in Neurology course, AAN Annual Meeting, 2001-
• Director, Ataxia: Whets and Hows of Acquired and Inherited Disease Course, AAN Annual Meeting, 2002-
• Member, Interdepartmental Programs in Neuroscience and Genetics at the University of Iowa

Professional Affiliations

• American Association for the Advancement of Science
• American Academy of Neurology
• Movement Disorder Society
• American Society of Human Genetics
• Society for Neurosciences

Clinical Interests

• Neurogenetics
• Movement Disorders
• Inherited Ataxias
• Co-Director, Huntington Disease Center of Excellence

Research Interests

• Therapeutics for neurodegenerative disease
• Molecular basis of hereditary neurodegenerative diseases, especially glutamine-repeat diseases
• Genetics of hereditary ataxias

Recent Publications/ Reviews
Chai Y, Shao Y., Miller V., Williams A., Paulson H. (2002) Live-cell imaging reveals divergent intracellular dynamics of polyglutamine disease proteins and supports a sequestration model of pathogenesis. Proc Natl Acad Sci 14: 9310-15.

Paulson, H., J.Y. Garbern, T.F. Hoban, K.M. Krajewski, R.A. Lewis, K.H. Fischbeck, R. I. Grossman, R. Lenkinski, J.A. Kamholz and M.E. Shy. (2002) Transient CNS white matter abnormality in X-linked Charcot-Marie-Tooth disease. Ann Neurol 52:429-34.

Xia, H., Mao, Q, Paulson, H.L., and Davidson, B.L. (2002) siRNA-mediated gene silencing in vitro and in vivo. Nature Biotech 20:1006-10.

Rüb U, De Vos RAI, Schultz C, Paulson H., Brunt E, Braak H (2002) Spinocerebellar ataxia type 3 (Machado-Joseph disease): Severe destruction of the lateral reticular nucleus. Brain 125:2115-2129.

Paulson, H.L. Diagnostic testing in neurogenetics. Principles, limitations, and ethical considerations. Neurol Clin. 2002 20(3):627-43.

Gonzalez-Alegre P., Miller V.H., Davidson B.L., and Paulson H.L. (2003) Toward therapy for DYT1 dystonia: Allele-specific silencing of mutant TorsinA. Ann Neurol 53:781-787.

Miller V.M., Xia H., Marrs G.L., Gouvion C.M., Lee G., Davidson B.L., and Paulson H.L. (2003) Allele Specific Silencing of Dominant Disease Genes. Proc Natl Acad Sci 100(12):7195-7200.

Shoesmith Berke, S. and Paulson, H. (2003) Protein aggregation and the ubiquitin proteasome pathway: gaining the UPPer hand on neurodegeneration. Curr Opin in Genet and Devel (in press).

Paulson, H. (2003) Polyglutamine neurodegeneration: Minding your Ps and Qs. Nature Medicine 7: 825-26

Address
Henry Paulson Lab
University of Michigan
4188 BSRB
109 Zina Pitcher Place
Ann Arbor, MI 48109
Phone: 734-615-5633
E-mail: henryp@umich.edu