William T. Talman, MD
Professor and VA Chief of Neurology
Neurobiology and Circulatory Control Laboratory
Address
Office location: S209 GH
Phone: 319-356-8750
Fax: 319-384-6269
E-mail: william-talman@uiowa.edu
Clinical Interests
Specialty: Autonomic Nervous System & Neurophysiology
Orthostatic hypotension
Autonomic dysfunction
Research Interests
- Central control of circulation
- Integration of cardiovascular and noncardiovascular reflexes
- Neurogenic hypertension
- The baroreceptor reflex in health and disease
- Central neurotransmitters
- Central neural regulation of cerebral blood flow
- The role of central excitatory amino acid receptors in the baroreceptor reflex
- Glycine and acetylcholine interactions in the brain stem
- Nitrosothiols as central neurotransmitters
- Neural modulation of cerebral blood flow
- Neurobiology and Circulatory Control Laboratory
Education
BA, The Virginia Military Institute, Lexington, Virginia
MD, The University of Virginia School of Medicine
Internship (Internal Medicine), Case Western Reserve University
Residency
(Internal Medicine), Case Western Reserve University
(Neurology), Cornell University
Fellowship
(Neurobiology), Cornell University
Honors and Awards
- The Society of Cincinnati Medal and Award, Virginia Military Institute, 1966
- Post-doctoral Fellowship, NIH, 1976-78
- Established Investigatorship, American Heart Association, 1981-86
- Elected active member of American Neurological Association, 1989
- Elected Fellow in American Academy of Neurology, 1996
- President, International Society for Autonomic Neuroscience 2003-2007
- Selected among "Best Doctors in America"
- Member of the Board of Directors of FASEB
- Member of the Board of Trustees of AAALAC
- President of Federation of American Societies for Experimental Biology
Professional Service
- Member Editorial Board, American Journal of Physiology Heart and Circulation Section, 1996-
- Member of Board, International Society for Autonomic Neuroscience, 1997-
- Member NIH Experimental Cardiovascular Sciences Study Section, 1999-
- Treasurer, International Society for Autonomic Neuroscience, 2000 - 2003
- Chair, Public Affairs Committee, American Physiological Society, 2000-
- Member Editorial Board of the journal Hypertension from 2002-
- Associate Editor for Cellular and Molecular Neurobiology, 2003-
Professional Affiliations
- The American Association for the Advancement of Science
- The Society for Neuroscience
- The American Heart Association (AHA)
- The American Academy of Neurology
- AHA Council on Basic Science
- AHA Council for High Blood Pressure Research (Elected Fellow 1986)
- AHA Council on Circulation
- The American Physiological Society
- The American Neurological Association
- International Society for Autonomic Neuroscience
- Federation of American Societies for Experimental Biology
Publications
Lin, L-H., Talman, W.T. Soluble guanylate cyclase and neuronal nitric oxide synthase colocalize in rat nucleus tractus solitarii. J.Chem.Neuroanat. 29:127-136, 2005
Lin, L-H., Talman, W.T. Nitroxidergic neurons in rat nucleus tractus solitarii express vesicular glutamate transporter 3. J.Chem.Neuroanat. 29:179-191, 2005
Lin, L-H., Talman, W.T. Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons. J. Chem. Neuroanat. 32(1):54-64, 2006
Talman, W.T. Nitric Oxide and Central Cardiovascular Control: a Simple Molecule with a Complex Story. Editorial Commentary. Hypertension 48(4):552-4, 2006.
Talman, W.T., Nitschke Dragon, D., Corr, J., Wang, D. Parasympathetic Stimulation Elicits Cerebral Vasodilatation in Rat. Autonomic Neuroscience: Basic and Clinical 2007 May 30;133(2):153-7.
Talman, W.T., Nitschke Dragon, D. Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension. Brain Research 1139:126-32.
Musch TI, Carroll RG, Just A, Lane PH, Talman WT.A broader view of animal research. BMJ. 2007 Feb 10;334 (7588):274
Lin, L-H, Taktakishvili, O. Talman, W.T. Identification and localization of cell types that express endothelial and neuronal nitric oxide synthase in the rat nucleus tractus solitarii. Brain Research 2007 1171:42-51.
Lin, L.-H., Taktakishvili, O., Talman, W.T. Colocalization of neurokinin-1, NMDA, and AMPA receptors on neurons of the rat nucleus tractus solitarii. Submitted – Neuroscience- 2008 Jun 23;154(2):690-700
Nayate, N., Moore, S.A., Weiss, R., Taktakishvili, O., Lin, L.-H., Talman, W.T. Cardiac Damage after Lesions of the Nucleus Tractus Solitarii. – Amer. J. Physiol. Reg. Integ. Physiol. 2009 Feb;296(2):R272-9.
Boysen, N.C., Nitschke Dragon, D., Talman, W.T. Parasympathetic Tonic Dilatory Influences on Cerebral Vessels. Autonom. Neurosci.: Basic and Clin. 147(1-2):101-4, 2009
Lin, L.-H., Langasek, J.E., Talman, L.S. Taktakishvili, O.M., Talman, W.T. Feline Immunodeficiency Virus as a Gene-Transfer Vector in the Rat Nucleus Tractus Solitarii, Cell. Mol Neurobiol. 30(3):339-346, 2010.
Taktakishvili, O.M., Lin, L.-H., Vanderheyden, A.D., Nashelsky, M.B., Talman, W.T. Nitroxidergic innervation of human cerebral arteries. Auton. Neurosci: Basic and Clin. 2010 Aug 25;156(1-2):152-3.
Lin LH, Dragon DN, Jin J, Talman WT. Targeting neurons of rat nucleus tractus solitarii with the gene transfer vector adeno-associated virus type 2 to up-regulate neuronal nitric oxide synthase. Cell Mol Neurobiol. 2011 Aug;31(6):847-59.