Residency
(Internal Medicine), Case Western Reserve University
(Neurology), Cornell University

Fellowship
(Neurobiology), Cornell University

Honors and Awards

• The Society of Cincinnati Medal and Award, Virginia Military Institute, 1966
• Graduated Distinguished with Honors in Biology, Virginia Military Institute, 1966
• Post-doctoral Fellowship, NIH, 1976-78
• Established Investigatorship, American Heart Association, 1981-86
• Elected Fellow in the Council for High Blood Pressure Research, AHA, 1986
• Elected Fellow in the Council on Circulation of the AHA, 1986
• Elected active member of American Neurological Association, 1989
• Clinical Investigatorship, Department of Veterans Affairs, 1992-97
• Elected Fellow in American Academy of Neurology, 1996
• M3 Teacher of the Year finalist, 1997
• Walter Cottman Fellow, Monash University, Melbourne, Australia, 1998
• Thomas L. O'Dunohue Lecturer, Howard University, College of Medicine, Washington, D.C., 2000
• Nominated 2002 to serve on Council of the American Physiological Society starting 2003
• President, International Society for Autonomic Neuroscience 2003-2007
• Selected among "Best Doctors in America"
• Member of the Board of Directors of FASEB
• Member of the Board of Trustees of AAALAC

Professional Activities / Editorial Boards

• Member Editorial Board, American Journal of Physiology Heart and Circulation Section, 1996-
• Member of Board, International Society for Autonomic Neuroscience, 1997-
• Member NIH Experimental Cardiovascular Sciences Study Section, 1999-
• Treasurer, International Society for Autonomic Neuroscience, 2000 - 2003
• Chair, Public Affairs Committee, American Physiological Society, 2000-
• Member Editorial Board of the journal Hypertension from 2002-
• Associate Editor for North America Cellular and Molecular Neurobiology, 2003-

Professional Affiliations

• The American Association for the Advancement of Science
• The Society for Neuroscience
• The American Heart Association (AHA)
• The American Academy of Neurology
• The Society for Cerebral Blood Flow and Metabolism
• AHA Council on Basic Science
• AHA Council for High Blood Pressure Research (Elected Fellow 1986)
• AHA Council on Circulation
• The American Physiological Society
• The Central Society for Neurological Research
• The American Neurological Association
• The Inter-American Society of Hypertension
• International Society for Autonomic Neuroscience

Clinical Interests
Specialty: Autonomic Nervous System & Neurophysiology
Orthostatic hypotension
Autonomic dysfunction

Research Interests

• Central control of circulation
• Integration of cardiovascular and noncardiovascular reflexes
• Neurogenic hypertension
• The baroreceptor reflex in health and disease
• Central neurotransmitters
• Central neural regulation of cerebral blood flow
• The role of central excitatory amino acid receptors in the baroreceptor reflex
• Glycine and acetylcholine interactions in the brain stem
• Nitrosothiols as central neurotransmitters
• Neural modulation of cerebral blood flow
• Neurobiology and Circulatory Control Laboratory

Recent Publications / Reviews
Victor, RG and Talman, WT. Comparative effects of clonidine and dihydroergotamine on venomotor tone and orthostatic tolerance in patients with severe hypoadrenergic orthostatic hypotension. Am. J. Med. 112: 361-368, 2002.

Talman, WT and Nitschke Dragon, D. Inhibiting the nucleus tractus solitarii extends cerebrovascular autoregulation during hypertension. Brain Res. 931:92-95, 2002.

Agassandian, K, Fazan, VPS, Adanina, V, and Talman, WT. Direct projections from the cardiovascular nucleus tractus solitarii to the superior salivatory nucleus: a link to cerebrovascular regulation. J. Comp. Neurol. 452:242-254, 2002.

Lin, L.H., Talman, W.T. Coexistence of NMDA and AMPA receptor subunits with nNOS in the nucleus tractus solitarii of rat. J. Chem. Neuroanat. 24:287-296, 2002.

Riley, J., Lin, L.H., Chianca, D.A.,Jr., Talman, W.T. NK1 receptors are critical in processing baroreflex signals in rat nucleus tractus solitarii. Hypertension. 40:823-826, 2002.

Bauman, NM, Deqiang, W., Luschei, ES and Talman, WT. The effect of substance P injection into the nucleus tractus solitarius of rats on laryngeal adductor activity and cardiovascular and respiratory systems. Ann. Otol. Rhinol. Laryngol. 111:875-883, 2002.

Lin, L.H., Agassandian, K., Fujiyama, F., Kaneko, T. and Talman, W.T. Evidence for glutamatergic input to pontine preganglionic neurons of the superior salivatory nucleus in rat. J. Chem. Neuroanat. 25:261-268, 2003.

Agassandian, K., Fazan, V.P.S., Margaryan, N., Nitschke Dragon, D., Riley, J., Talman, W.T. A Novel Central Pathway Links Arterial Baroreceptors and Pontine Parasympathetic Neurons in Cerebrovascular Control. Cell. Mol. Neurobiol. 23:463-479, 2003.

Talman, W.T. Glutamate and blood pressure in multiple system atrophy. (Editorial) Clin. Auton. Res. 13:239-241, 2003.

Lin, L.H., Edwards, R.H., Fremeau, R.T.J., Fujiyama, F., Kaneko, T., Talman, W.T. Vesicular Glutamate Transporter Colocalizes with Neuronal Nitric Oxide Synthase in Rat Nucleus Tractus Solitarii. Neuroscience. 123: 247-255, 2004.

Chianca, D.A., Jr., Lin, L.H., Nitschke Dragon, D., Talman, W.T. Glutamate Receptors in the Nucleus Tractus Solitarii are Linked to Soluble Guanylate Cyclase. Am. J. Physiol. Heart & Circ. Physiol. 286: H1521-1527, 2004.

Talman, W.T., Nitschke Dragon, D. Transmission of arterial baroreflex signals depends on neuronal nitric oxide synthase. Hypertension. 43:820-824, 2004.

Lin, L.H., Talman, W.T. Soluble guanylate cyclase and neuronal nitric oxide synthase colocalize in rat nucleus tractus solitarii. J.Chem.Neuroanat. 29:127-136, 2005.

Lin, L.H., Talman, W.T. Nitroxidergic neurons in rat nucleus tractus solitarii express vesicular glutamate transporter 3. J. Chem. Neuroanat. 29:179-191, 2005.

Lin, L.H., Talman, W.T. Vesicular glutamate transporters and neuronal nitric oxide synthase colocalize in aortic depressor afferent neurons. J. Chem. Neuroanat. 32(1):54-64, 2006.

Talman, W.T. Nitric Oxide and Central Cardiovascular Control: a Simple Molecule with a Complex Story. Editorial Commentary. Hypertension. 48(4):552-4, 2006.

Talman, W.T., Nitschke Dragon, D., Corr, J., Wang, D. Parasympathetic Stimulation Elicits Cerebral Vasodilatation in Rat. Autonomic Neuroscience: Basic and Clinical 2007 May 30;133(2):153-7.

Talman, W.T., Nitschke Dragon, D. Selective Neuronal Nitric Oxide Synthase Inhibition Attenuates Breakthrough of Autoregulation during Acute Hypertension. Brain Research. 1139:126-132, 2007.

Musch TI, Carroll RG, Just A, Lane PH, Talman, W.T. A broader view of animal research. BMJ. 2007 Feb 10;334 (7588):274.

Chapters
Talman, W.T., Davis PH. Myocardial damage and cardiac arrhythmias. In: Office Practice of Neurology. M. A. Samuels, S. Feske (Eds). New York: Churchill Livingstone, pp. 1199-1201, 2003.

Talman, W.T. Cardiac arrhythmias and sudden death. In: Neurological Therapeutics: Principles and Practices, John Noseworthy and M.A. Samuels (eds). Section VIII, I (b.). Martin Dunitz Publishers, pp.1255-1257, 2003.

Heistad DD, Lawton WJ, Talman, W.T. Pathogenesis of Acute Hypertensive Encephalopathy. In: Handbook of Hypertension J.L. Izzo & H.R. Black (eds). Lippincott Williams & Wilkins, Philadelphia, pp 201-203, 2003.

Talman, W.T. Parasympathetic Influences on Cerebral Circulation: a Link to Arterial Baroreflexes. In: Neural Control of Circulation N Dun (ed). Kluwer, Boston, pp 357-370, 2004.

Talman, W.T. Amino acid neurotransmission. In: Primer on the Autonomic Nervous System (2nd ed). D. Robertson, I. Biaggioni, G. Burnstock, and P.A. Low (eds). Elsevier Academic Press, Boston, pp 81-82, 2004.

Talman, WT, Lin, L.H. Glutamatergic and nitroxidergic neurotransmission in the nucleus tractus solitarii. In: Neurobiology of DOPA as a Neurotransmitter, Progress in Pharmacology and Toxicology. Misu, Y and Goshima, Y (eds) CRC Press, London, 2004.

Address
Office location: S209 GH
Phone: 319-356-8750
Fax: 319-384-6269
E-mail: william-talman@uiowa.edu