Division of Medical Genetics

Val Sheffield, MD PhD, Director

Cytogenetics Laboratory
Division of Medical Genetics
Department of Pediatrics
University of Iowa Hospitals and Clinics (UIHC)
W101 GH, 200 Hawkins Dr.
Iowa City, IA 52242

Accreditation/Certification/Proficiency Testing

  • Accredited by the College of American Pathologists (CAP)
  • Certified under the Clinical Laboratory Improvements Amendments of 1988
  • Participate in the CAP Cytogenetics Proficiency Testing (PT) Program
  • Director of the laboratory is board certified in Clinical Cytogenetics by the American Board of Medical Genetics

Laboratory Director

Shivanand R. Patil, Ph.D., Director
E-mail: shivanand-patil@uiowa.edu

Laboratory Supervisor/Contact Person

Richard Van Rheeden, BS, MS
Phone: 319-356-3877
richard-vanrheeden@uiowa.edu

Technical Staff Members

  • Technologists are well versed in the field of cytogenetics and experienced in laboratory methodology; technologists are certified as Clinical Laboratory Specialists in Cytogenetics (CLSpCG).
  • Technologists receive continuing education from attending national and regional meetings, national teleconferences, university seminars, in-house conferences, and participating in monthly laboratory's journal club.

Commitment to providing high quality cytogenetic services at competitive costs

  • Outstanding relationships and interaction with referring clinicians (obstetricians, neonatologists, oncologists, pathologists, etc., as well as with other health care professionals).
  • Provides educational and scientific materials to referring clinicians as needed on unusual cases for the purpose of aiding counseling and education.
  • Lowest failure (no results) rates on specimens received for chromosome analysis.
  • Participate in Children's Oncology Group (COG) and Cancer of Leukemia Group B (CALGB).
  • Certified as reference laboratory by COG and CALGB.

Reporting of Results

  • Verbal preliminary results are given in 24-48 hours based on 10 cells for specimens with hematological malignancies and newborns suspected of trisomies.
  • A written interpretive report of the lab results is available in IPR (Display Documents for a patient) for UIHC patients.
  • A written report is mailed or faxed to the referring physician at outside hospitals.
  • The turnaround times for the final report by specimen type are shown in the accompanying table.

Confidentiality

  • The Cytogenetics laboratory is fully committed to maintaining patient confidentiality.

Consultation

  • Consultation is available through our laboratory from our board certified clinical/molecular/biochemical geneticists and genetic counselors in the Division of Medical Genetics (319-356-2674 phone).

Requesting Cytogenetic Testing

  • A C-12 Cytogenetics Request form (available from our laboratory) must accompany each specimen.
  • All specimens should be sent at room temperature.Do not freeze or centrifuge.

Billing

  • Laboratory fees are submitted to the UIHC Joint Office of Patient Financial Services for processing.
  • Complete patient insurance information must accompany all outside specimens (insurance and authorization forms are attached to the C12 request form).
  • If preferred, arrangements can be made to bill directly to the referring lab or institution.

Hours

  • Weekdays:
    Monday-Friday
    8:00 a.m.-5:00 p.m.

  • Weekends/Holidays:
    technologists are on week-end call

Phone and Fax

  • (319) 356-3877
  • (319) 353-6704 (Fax)
  • 1-888-533-0186 (Pager--weekends and holidays only); press the # sign after you enter your phone number

FISH

Test Menu, Specimen Type, and Turnaround Times

Test and Specimen Type Turn Around Times
(Days for Final Results)
Chromosome Analysis
Amniotic Fluid 10-12 Days
Bone Marrow (for acquired and constitutional abnormalities) 14 Days
Cell Culture (Biochemical and Molecular Studies)
Chorionic Villi 10-12 Days
Fetal Blood (Prenatal Diagnosis) 7 Days
Peripheral Blood (Breakage Studies, Fanconi, AT) 14-21 Days
Peripheral Blood, Cord Blood (Constituional Abnormalities) 7-14 Days
Peripheral Blood for Hematological Disorders 14 Days
Product of Conception (POC) 21-30 Days
Skin, Other Tissue (Constitutional Abnormalities) 21-30 Days
Skin or Internal Tissue or Blood from Autopsy (Constitutional Abnormalities) 21-30 Days (tissues)
14-21 Days (blood)
FISH (Fluorescence In-Situ Hybridization)
Amniocytes, Chorionic Villi (Prenatal-Aneuploidy/Microdeletion) 2-10 Days
Bone Marrow 3-5 Days
Peripheral Blood (Hematological) 3-5 Days
Peripheral Blood (Newborn or Cord, and Others) (Aneuploidy Screening) 2-5 Days
Peripheral Blood, Bone Marrow, Fibroblasts, Other Tissue (Microdeletion and subtelomeric constitutional studies) 5-7 Days
Tumor Tissue (Fresh Tissue) 7-14 Days
Tumor Tissue (Paraffin Embedded Tissue Slides) 3-10 Days
Voided Urine, Bladder Wash (Bladder Carcinoma) 4-8 Days
Chromosome Micro Array (CMA)
 
Peripheral Blood (Purple Top)-for Constitutional Abnormalities 4 weeks

Shipping

  • Specimens should be sent by overnight courier. If arrival will occur on the weekend, specimens should be delivered to Specimen Control, UIHC, 6240 RCP, ATTN: Cytogenetics Lab. Please call the Cytogenetics Laboratory and leave patient name, specimen type, referring physician's name and phone number, and tracking number of courier recorded on our voice mail.
  • We can provide a Fed Ex account number for shipping charges.

Supplies

  • Styrofoam mailers are available from our laboratory for out-of-hospital clients (contact the laboratory for specific details).

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Last modification date: Thu Jun 26 10:58:00 2008
URL: http://www.uihealthcare.com /depts/med/pediatrics/divisions/cytogenetics.html