Heather Bartlett, MD
Research Profile
Assistant Professor of Pediatrics
Director, Pediatric Cardiology Fellowship Program
Contact Information:
Office Phone - 319-356-2845
Laboratory Phone 319-335-7919
Fax - 319-356-4693
E-mail: heather-bartlett@uiowa.edu
Education/Training
University of Arizona, Medical/Graduate School
University of Arizona, Residency and Postdoctoral Fellowship
University of Iowa, Fellowship, Pediatric Cardiology
Appointment December 2004
Clinical Interests
Congenital and acquired heart in children; adults with congenital heart disease; connective tissue disorders, heart transplantation.
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Research Interests
Research in our laboratory centers on cardiac development and the origins of congenital heart disease. Areas of focus include identification and characterization of genes critical to development and physiology of the embryonic conduction system. Current studies concentrate on the role of the transcription factor, Nkx 2.5, on development of the embryonic cardiac conduction system. We utilize an array of techniques to modulate gene expression and monitor cardiac development through embryogenesis to adulthood.
Confocal micrograph of a stage 46 Xenopus heart. Staining for actin (blue) and acetylated tubulin (green) allows imaging of the heart and conduction system, that starts high in the right atrium, bridges the atrioventricular junction and bifurcates into two branches in the ventricle (arrows).
Lab Members:
Elesa Wedemeyer
Collaboration with the laboratory of Dan Weeks, Ph.D.
Affiliations:
Model System: Xenopus laevis and Xenopus tropicalis
Recent Publications:
- Bartlett, H., Scholz T. Lamb F. Weeks D. Characterization of embryonic cardiac pacemaker and atrioventricular conduction physiology in Xenopus laevis using noninvasive imaging. Am J Physiol Heart Circ Physiol, 2004. 286(6): p. H2035-41.
- Kirklin J, Naftel D, Pearce F, White-Williams C, Caldwell R, Bartlett, H, Rusconi P, Robinson B, Should Status 2 Patients Be Removed From the Pediatric Heart Transplant Waiting List: A Multi-institutional Study, J Heart Lung Transplant 2006 25(3):271-5.
- Bartlett, H, Atkins D, Burns T, Engelkes K, Larson S, Hills C, Moller J, Early Outcomes of Tricuspid Valve Replacement in Young Children, Circulation, in press 2007.
- Bartlett HL, Sutherland L, Kolker S, Littig J, Tajchman U, Ogniwski V, Weeks D. Transient Early Embryonic Expression of Nkx 2.5 Mutations Linked to Congenital Heart Defects in Human Causes Heart Defects in Xenopus Laevis. Developmental Dynamics, 2007 Sep;236(9):2475-84.
- Patel PM, Bartlett HL, Scholz TD, Burzynski J, Behrendt, DM, Burkhart, HM. Norwood Modification in a Patient with Hypoplastic Left Heart and a Right Aortic Arch. J Thorac Cardiovasc Surg. 2007 Oct;134(4):1065-6.
- Von Bergen NH, Burkhart HM, Latson LA, Emery SP, Youoszai AK, Bartlett HL. Complete Cavopulmonary Shunt Completion After In-utero Balloon Atrial Septoplasty for Hypoplastic Left Heart Syndrome. J Thorac Cardiovasc Surg November 2007;134(5):1355-6.
- Bartlett HL, Mahoney LT, Skorton DJ, (2008) Congenital Heart Disease in Cardiovasular Medicine, Chapter XV. American College of Physicians Medicine BC Decker Inc.
- Bartlett HL, Escalera RB, Patel SS, Wedemeyer EW, Volk KA, Lohr JL, Weeks DL Reinking BE. Echocardiographic Assessment of Cardiac Morphology and Function in Xenopus. In preparation
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