Titles
Director, Child Neurology Residency Program
Professor of Pediatrics and Neurology
Education
BS – University of Iowa; 1982
MD – University of Iowa; 1990
PhD – University of Iowa; 1990
Postgraduate Training
Residency – University of Virginia
Neurology Residency – University of Iowa
Fulbright Fellowship in Neuroanatomy – University of Otago
Postdoctoral Fellowship in Neuroscience – University of Virginia
Child Neurology Fellowship – University of Iowa
Clinical Interests
- Pediatric Neurology
- Neonatal Neurology
- Neurologic Birth Defects
Research Interests
Central nervous system development and the factors that can disrupt it. I focus my research on two neuroteratogenic agents: alcohol (fetal alcohol syndrome) and lymphocytic choriomeningitis virus (congenital LCMV infection). Investigating the cellular and molecular mechanisms underlying alcohol- and LCMV-induced injury to the developing brain, the behavioral consequences of these injuries, and therapeutic agents to minimize or reverse the injuries.
The development of gene therapy for neurological diseases. In particular, I am exploring the use of viral gene therapy vectors for the treatment of Alexander Disease, a devastating genetic disease of the pediatric brain.
Lab Members:
- Bahri Karacay, PhD
- Glenda Rabe, MD
- Shenglan Li, BS, MA
- Jo Mahoney, BS
- Hannah Klein de Licona, BS
- Mark Luong
- Arya Ordoubadian
Affiliations:
- Neuroscience Program
- Medical Scientist Training Program
- Department of Neurology
- Cellular and Molecular Biology Program
Model System
We utilize animal model systems and tissue culture systems of fetal alcohol syndrome, congenital LCMV infection, and Alexander Disease.
Recent Publications
Back to the Department of Pediatrics
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Division of Child Neurology
Child Neurology Residency Program
Recent Publications
Contact Information:
E-mail: daniel-bonthius@uiowa.edu
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