John M. Dagle, MD, PhD
Research Profile
Contact Information:
Office: 319-353-7009
Fax: 319-356-4685
Lab: 319-335-8154
E-mail: john-dagle@uiowa.edu
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Education and Training
Predoctoral and Doctoral Education
1980-1984 Creighton University Omaha, NE Chemistry, BS
1984-1991 University of Iowa College of Medicine Iowa City, IA Medicine, MD
1984-1991 University of Iowa College of Medicine Iowa City, IA Biochemistry, PhD
Postgraduate Medical Education
1992-1994 University of Iowa Hospitals and Clinics Iowa City, IA Pediatric Residency
1995-1997 University of Iowa Hospitals and Clinics Iowa City, IA Neonatology Fellowship
Research Interests:
- Antisense oligonucleotide and siRNA technology
- Early vertebrate development
- The genetics of prematurity
Lab Members:
- John M. Dagle, MD, PhD
- Nathan Lepp, MD
Affiliations:
Model System:
Xenopus laevis
Recent Publications:
- Klein JM, McCarthy TA, Dagle JM, Snyder JM. Antisense inhibition of surfactant protein A decreases tubular myelin formation in human fetal lung in vitro. Am J Physiol, 282(3):L386-L393; 2002.
- Murphy CR, Sabel JL, Sandler AD, and Dagle JM. Survivin mRNA is downregulated during early Xenopus laevis embryogenesis. Dev Dynamics, 225:597-601; 2002.
- Dagle JM, Sabel JL, Littig, JL, Sutherland LB, Kolker SJ, Weeks DL. Pitx2c attenuation results in cardiac defects and abnormalities of intestinal orientation in developing Xenopus laevis. Dev Biol, 262:268-281; 2003.
- Dong Q, Stellwagen E, Dagle JM, Stellwagen NC. Free solution mobility of small single-stranded oligonucleotides with variable charge densities. Electrophoresis, 24: 3323-3329; 2003.
- Shi M, Caprau D, Dagle JM, Christiansen L, Murray JC, Christensen K. Application of kinetic PCR and molecular beacon assays to pooled analyses and high-throughput genotyping for candidate genes. Birth Defects Research (Part A): Clinical and Molecular Teratology, 70:65-74;2004.
- Lennox KA, Sabel JL, Johnson MJ, Moreira BG, Fletcher CA, Rose SD, Behlke MA, Laikhter AL, Walder JA, and Dagle JM. Characterization of modified antisense oligonucleotides in Xenopus laevis.
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