Title
Assistant Professor of Pediatrics
Education
BA – Cornell College; 1996
MD – University of Iowa; 2000
Postgraduate Training
Residency – University of Iowa
Pediatric Critical Care Fellowship – University of Iowa
Clinical Interests
ARDS, Sepsis management
Research Interests
The Volk laboratory studies innate immunity, focusing on neutrophil function. The requirement for normal PMN function in the innate immune response has been demonstrated unequivocally.
PMN chemotaxis is essential during the immune response to sepsis. The anion transporters ClC-3 and IClswell appear to be required for normal PMN chemotaxis. The central hypothesis of this work is that cell volume regulation via the swelling-induced chloride current, IClswell, is required for normal PMN chemotaxis and that ClC-3 modulates this process. Several key neutrophil functions, including chemotaxis, transendothelial migration, phagocytosis and priming, are studied using a variety of techniques. Neutrophil chemotaxis is our primary interest and this is studied using two complimentary assays, the high-through-put EZ-TAXIScan and the high-resolution Dynamic Imaging Analysis System (DIAS).
Lab Members
- Jessica Moreland, MD (Mentor)
- Fred Lamb, M.D., Ph.D. (Co-Mentor)
- Christine Heise (Volk lab Research Assistant)
- Jessica Hook (Moreland lab Research Assistant)
- Brieanna Barber (Moreland lab Research Assistant)
Affiliations
- Department of Pediatrics, Division of Critical Care
- The Inflammation Program
- Department of Internal Medicine, Division of Infectious Disease
- Veteran's Administration
Model System
The primary model systems used in the Volk laboratory include:
- Human neutrophils treated with pharmacological inhibitors of the anion channels ClC-3 and IClswell.
- Murine neutrophils from wild type and ClC-3 knock-out mice developed in the Lamb laboratory.
Recent Publications
Electronic Publications:
- Davis AP: Review of Malerba, G., Romano-Girard, F., Cravoisy, A., Dousset, B., Nace, L., Levy, B., Bollaert, P.: Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. Intensive Care Medicine. 31:388-392. 2005. http://pedsCCM.wustl.edu/EBJ/PREDICTION/Malerba-adrenal.hmtl Pediatric Critical Care Medicine Evidence-Based Journal Club.
- D'Alessandro DM, Davis AP. What are the Current Recommendations for Treatment of Acute Traumatic Head Injury?. PediatricEducation.org. Available from the Internet at: http://www.pediatriceducation.org/2007/11/05 (rev. 11/5/07, cited 11/5/07).
Back to Department of Pediatrics
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Division of Critical Care
Recent Publications
Contact Information:
Office: 319-356-4190
Fax: 319-353-8597
Lab: 319-335-4576
E-mail: paige-volk@uiowa.edu
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