Jonathan M. Klein, MD
Research Profile
Associate Professor of Pediatrics
Medical Director of the Neonatal Intensive Care Unit
Medical Director, Nurse Practitioner Program in the Special Care Nurseries
Contact Information:
Office: 319-356-3340
Fax: 319-356-4685
Lab: 319-335-7737
E-mail: jonathan-klein@uiowa.edu
Education and Training
1976-1980; Johns Hopkins University; BA
1980-1984; Medical College of Virginia; MD
1984-1987; Children's Medical Center of Dallas; Residency (Pediatrics); Univ. Texas SW Medical Center
1987-1990; Division of Newborn Medicine; Fellowship (Neonatology); Department of Pediatrics, Tufts University
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Research Interests:
- Epidermal growth factor regulation of fetal lung development
- The effect of androgens on epidermal growth factor receptor binding and gene expression during fetal lung development
- Sex-specific gene expression during human fetal lung development
- High Frequency Ventilation
- Surfactant replacement therapy for Post-Surfactant Slump
- Oxygen Saturation Targeting
- Genetic variation responsible for persistent pulmonary hypertension of the newborn
Research Team /Lab Members:
Troy McCarthy (Pediatrics/Neonatology)
Research Affiliations:
Model System:
- Explant culture model, translational research, human trials
Recent Publications:
- Ellsbury DL, Klein JM. Oxygen-saturation targets in extremely preterm infants. N Engl J Med 2003;349:24.
- Ellsbury DL, Acarregui MJ, McGuinness GA, Eastman DL, Klein JM. Controversy surrounding the use of home oxygen for premature infants with bronchopulmonary dysplasia. J Perinatol, 2004;24:36-40.1.
- Garbrecht MR, Klein JM, Schmidt TJ, Snyder JM. Glucocorticoid metabolism in the human fetal lung: Implications for lung development and the pulmonary surfactant system. Biol Neonate, 2006;89:109-119.1.
- Katz LA, Klein JM. Repeat surfactant therapy for post-surfactant slump. J Perinatol, 2006; 26:414-422.
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