Assistant Professor
Depts of Biology and Pediatrics

Education

• PhD, Columbia University

Postgraduate Training

• Post-doctoral studies, Stanford University School of Medicine

Research Interests

• Genomics and genetics of human disease, fly models of human disease, genomics technology development.

Lab Members

• Juan Santana, Steve Butcher, Xiaojing Hong, Salleh Ehaideb, Jason Dierdorff, Matt Hakeman, Kaila Pomeranz, Bryan Cobb, Matthew Christie, Andrew Weber, Xue Xiao.

Affiliations

• Biology, Pediatrics
• Model System
• Drosophila melanogaster

Recent Publications

Tao H*, Manak JR*, Sowers L*, Mei X, Kiyonari H, Abe T, Dahdaleh NS, Yang T, Wu S, Chen S, Fox MH, Gurnett C, Montine T, Bird T, Shaffer LG, Rosenfeld JA, McConnell J, Madan-Khetarpal S, Berry-Kravis E, Griesbach H, Saneto RP, Scott MP, Antic D, Reed J, Boland R, Ehaideb SN, El-Shanti H, Mahajan VB, Ferguson PJ, Axelrod JD, Lehesjoki A-E, Fritzsch B, Slusarski DC, Wemmie J, Ueno N and Bassuk AG. 2011. PRICKLE orthologues cause seizures in flies, mice and humans. Am J Hum Genet 88: 1-12. *co-first authors

Colbourne JK, Pfrender ME, Gilbert D, Thomas WK, Tucker A, Oakley TH, Tokishita S, Aerts A, Arnold GJ, Basu MK, Bauer, DJ, Cáceres CE, Carmel L, Casola C, Choi J-H, Detter JC, Dong Q, Dusheyko S, Eads BD, Fröhlich T, Geiler-Samerotte KA, Gerlach D, Hatcher P, Jogdeo S, Krijgsveld J, Kriventseva EV, Kültz D, Laforsch C, Lindquist E, Lopez J, Manak JR, Muller J, Pangilinan J, Patwardhan RP, Pitluck S, Pritham EJ, Rechtsteiner A, Rho M, Rogozin IB, Sakarya O, Salamov A, Schaack S, Shapiro H, Shiga Y, Skalitzky C, Smith Z, Souvorov A, Sung W, Tang Z, Tsuchiya D, Tu H, Vos H, Wang M, Wolf YI, Yamagata H, Yamada T, Ye Y, Shaw JR, Andrews J, Crease TJ, Tang H, Lucas SM, Robertson HM, Bork P, Koonin EV, Zdobnov EM, Grigoriev IV, Lynch M and Boore JL. 2011. The ecoresponsive genome of Daphnia pulex. Science 331: 555-561.

Denoeud F, Henriet S, Mungpakdee S, Aury JM, Da Silva C, Brinkmann H, Mikhaleva J, Olsen LC, Jubin C, Cañestro C, Bouquet JM, Danks G, Poulain J, Campsteijn C, Adamski M, Cross I, Yadetie F, Muffato M, Louis A, Butcher S, Tsagkogeorga G, Konrad A, Singh S, Jensen MF, Cong EH, Eikeseth-Otteraa H, Noel B, Anthouard V, Porcel BM, Kachouri-Lafond R, Nishino A, Ugolini M, Chourrout P, Nishida H, Aasland R, Huzurbazar S, Westhof E, Delsuc F, Lehrach H, Reinhardt R, Weissenbach J, Roy SW, Artiguenave F, Postlethwait JH, Manak JR, Thompson EM, Jaillon O, Du Pasquier L, Boudinot P, Liberles DA, Volff JN, Philippe H, Lenhard B, Crollius HR, Wincker P, and Chourrout D. 2010. Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate. Science 330: 1381-1385.

Pomerantz, MM, Ahmadiyeh N, Jia L., Herman P., Verzi MP, Doddapaneni H, Beckwith CA, Chan JA, Hills A, Davis M, Yao K, Kehoe SM, Haiman CA, Yan C, Henderson BE, Frenkel B, Barretina J, Bass A, Tabernero J, Baselga J, Regan MM, Manak JR, Shivdasani R, Coetzee GA and Freedman ML. 2009. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat. Genet. 41: 882-884

Jia L, Landan G, Pomerantz M, Jaschek R, Herman P, Reich D, Yan C, Khalid O, Kantoff P, Oh W, Manak JR, Berman BP, Henderson BE, Frenkel B, Haiman CA, Freedman M, Tanay A and Coetzee GA. 2009. Functional enhancers at the gene-poor 8q24 cancer-linked locus. PLoS Genet. 5: e1000597.

Kwong C, Adryan B., Meadows L, Bell I, Russell S, Manak JR, White R. 2008. Stability and dynamics of Polycomb target sites in Drosophila development. PLoS Genet. 4: e1000178.

Georlette D, Ahn S, MacAlpine DM, Cheung E, Lewis PW, Beall EL, Speed T, Manak JR and Botchan MR. 2007. Genomic profiling and expression studies reveal both positive and negative roles for the Drosophila Myb-MuvB/dREAM complex in proliferating cells. Genes Dev. 21: 2880-2896.

Manak JR, Wen H, Van T, Andrejka L and Lipsick JS. 2007. Loss of Drosophila Myb Interrupts the progression of chromosome condensation. Nat. Cell Biol. 9: 581-587.

Manak JR*, Dike S, Sementchenko V, Kapranov P, Biemar F, Long J, Cheng J, Bell I, Ghosh S, Piccolboni A and Gingeras TR. 2006. Biological Function of Unannotated Transcription During the Early Development of Drosophila melanogaster. Nat. Genet. 38: 1151-1158.

*corresponding author.

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