Titles
Director, Department of Pediatric Fellowship Education
Director, Critical Care Fellowship Program
Associate Professor of Pediatrics
Education
BS – Duke University; 1988
MD – Vanderbilt University Medical Center; 1992
Postgraduate Training
Residency – Vanderbilt University Medical Center
Pediatric Critical Care Fellowship – Vanderbilt University Medical Center
Clinical Interests
Pediatric respiratory failure, alternative modes of ventilation and ECMO.
Research Interests:
The primary focus of our laboratory is to understand the role of the anion channel ClC-3 in neutrophil function, including the interaction between ClC-3 and the NADPH oxidase. This interest developed after ClC-3 knockout mice were found to have a defect in innate immunity and later demonstrated to have multiple abnormalities in neutrophil function. There are several sub-projects under study including:
Role of anion channels in cell volume regulation and cell motility in neutrophils
Collaborators include:
Fred S. Lamb, M.D., Ph.D., University of Iowa, Dept. of Pediatrics
A. Paige Davis, M.D., University of Iowa, Dept. of Pediatrics
William M. Nauseef, M.D., University of Iowa, Department of Internal Medicine
David R. Soll, Ph.D., University of Iowa, Dept of Biology
Role of anion channels and oxidants in neutrophil priming by endotoxin
Collaborators include:
Fred S. Lamb, M.D., Ph.D., University of Iowa, Dept. of Pediatrics
Francis Miller, M.D. University of Iowa, Department of Internal Medicine
A second ongoing project in the laboratory focuses on understanding the early components of the innate immune response to bacterial pathogens in the lung. We are specifically interested in dissecting neutrophil-endothelial cell interactions, and understanding the determinants of neutrophil transendothelial migration. These studies focus on two very distinct pulmonary pathogens: Streptococcus pneumoniae, the leading cause of community acquired pneumonia, and Francisella tularensis, a potential agent for bioterrorism. We have developed an in vitro model of neutrophil transmigration that includes stimulation of primary human pulmonary endothelial cells with live bacteria, followed by the addition of human PMNs
Lab Members:
- Jessica Hook, BS, MS (Research Assistant II)
- Brieanna Barber, BS (Research Assistant I)
Affiliations:
Recent Publications
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