M. Sue O'Dorisio, MD, PhD
Research Profile
Research Interests:
Our goal in both basic research and in clinical research is to improve the length and quality of life for children with nervous system tumors. This involves studies of 1) neural crest and cerebellar development; 2) exploitation of neuropeptide receptors as diagnostic and therapeutic targets; and 3) clinical trials of new imaging agents and new therapeutic modalities for nervous system tumors, especially neuroblastoma and medulloblastoma.
Lab Members:
We currently have one postdoctoral fellow, a medical student, a neuroscience graduate student, two undergraduate students, and two technicians on our team. We frequently have fellows or young faculty from other departments working in our laboratory as well.
Affiliations:
 Model System:
- We have cell culture and animal models of neuroblastoma and medulloblastoma.
- We use a knockout mouse model to study neural crest differentiation.
- We conduct Phase I Trials of molecularly targeted therapies in neuroblastoma and brain tumors.
Clinical Trials
 Recent Publications:
- Frühwald MC, Rickert CH, O'Dorisio MS, Madsen M, Warmuth-Metz M, Khanna G, Paulus W, Kühl J, Jürgens H, Schneider P, Müller HL: Somatostatin receptor subtype 2 is expressed by supratentorial primitive neuroectodermal tumors of childhood and can be targeted for somatostatin receptor imaging. Clinical Cancer Research 10:2997-3006, 2004.
- Karacay B, O'Dorisio MS, Summers M, Robinson M, Bonthius DJ: VIP receptor 1 (VPAC1) promoter targets the expression of a reporter gene to cerebellum and adrenal medulla in transgenic mice. Regulatory Peptides 116:1-12, 2003.
- Sall JW, Klisovic DD, O'Dorisio MS: Somatostatin inhibits IGF-1 mediated induction of VEGF in human retinal pigment epithelial cells. Experimental Eye Research, 79(4): 465-476, 2004.
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