Brian C. Schutte, PhD
Research Profile

Research Interests

• Vertebrate development
• Genetics of craniofacial development
• Genetics of cleft lip and palate
• Regulation of epithelial cell proliferation and differentiation

Research Team/Lab Members

• Martine Dunnwald, Research Scientist, Department of Pediatrics
• Akira Kinoshita, Post-doc, Department of Pediatrics
• Nick Rorick, Graduate Student, Genetics PhD Program
• Kurt Trout, Research Assistant, Department of Pediatrics

Research Affiliations

• Department of Pediatrics, Division of Cardiology
• Interdisciplinary PhD Program in Genetics
• Child and Family Health, College of Nursing
• Child Health Research Center Core Laboratory, Director

Model System

• Gene knockout models in mouse to study gene function.
• Gene knockdown and ectopic expression in zebrafish to study gene function.
• In vitro models of transcription factor binding to DNA.
• Cell culture models for transactivation activity of transcription factors.
• Tissue culture models for fusion of palate.
• Computer models to study structure/function of transcription factor.

Recent Publications (past 3 years)

1. Ingraham, CR, A Kinoshita, S Kondo, B Yang, S Sajan, KJ Trout, MI Malik, M Dunnwald, SL Goudy, M Lovett, JC Murray & BC Schutte (2006) Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6). Nat. Genet. 38:1335-1340.
2. Kayano,S, S. Kure, Y Suzuki, K Kanno, Y. Aoki, S Kondo, BC Schutte, JC Murray, A Yamada, Y Matsubara (2003) Novel IRF6 mutations in Japanese patients with Van der Woude Syndrome: Two missense mutations (R45S and P369S) and a 17-kb deletion. J. Hum. Genet. 48: 622-628.
3. Ralphe, JC, JL Segar, BC Schutte, TD Scholz (2004) Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria. J. Mol. Cell Cardiol. 37: 33-41.
4. Shanske, AL, SA Hoper, K Krahn, BC Schutte (2004) Mutations in IRF6 do not cause Bartsocas-Papas Syndrome in a family with two affected sibs. Am. J. Med. Genet. 128A: 431-433.
5. Zucchero, TM, ME Cooper, BS Maher, S Daack-Hirsch B Nepomuceno, L Ribeiro, DCaprau, K Christensen, Y Suzuki, J Machida, N Natsume, K Yoshiura, AR. Vieira, IM. Orioli, EE. Castilla, L Moreno, M Arcos-Burgos AC. Lidral, LL Field, Y Liu, A Ray, TH Goldstein, RE Schultz,,M Shi, S Kondo, BC Schutte, ML Marazita, JC Murray (2004) Interferon Regulatory Factor 6 (IRF6) is a Modifier for Isolated Cleft Lip and Palate. New England J. Med. 351: 769-780.
6. DiPaola, J, S Patil, BC Schutte (2004) Breakpoint of a Balanced Translocation (X: 14) (q27.1; q32.33) in a Girl with Severe Hemophilia B Maps Proximal to the Factor IX Gene. J. Throm. And Haem. 2: 437-40.
7. Kantaputra, PN, C Limwongse, A Assawamakin, O Praditsap, U Kemaleelakul, S Kondo, BC Schutte (2004) A novel mutation in IRF6 underlies hearing loss, pulp stones, large craniofacial sinuses, and limb anomalies in Van der Woude Syndrome patients. Oral Biosciences & Medicine. 4: 277-282.
8. Bailey, CM, Z Khalkhali-Ellis, S Kondo, N Margaryan, RE Seftor, WW Wheaton, S Amir, MR Pins, BC Schutte, MJ Hendrix (2005) Maspin binds directly to interferon regulatory factor 6: Identification of a novel serpin partnership. J Biol Chem In press.
9. Knight, A.S., BC Schutte, R Jiang, & MJ Dixon (2006) Developmental expression analysis of the mouse and chick orthologues of IRF6: The gene mutated in Van der Woude syndrome. Dev Dyn. 235:1441-1447.