Jeffrey L. Segar, MD
Research Profile
Professor of Pediatrics
Director, Division of Neonatology
Contact Information:
Office Tel: 319-356-7244
Fax: 319-356-4685
Lab Tel: 319-335-6997
jeffrey-segar@uiowa.edu
Education and Training
| 1978-1980 |
Cornell University, Ithaca, NY |
| 1980-1982 |
University of Wisconsin, Madison
Zoology, BS |
| 1982-1986 |
University of Wisconsin, Madison
Medicine, MD |
| 1986-1989 |
University of Iowa, Iowa City, IA
Residency (Pediatrics) |
| 1989-1992 |
University of Iowa, Iowa City, IA
Fellow (Neonatology) |
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Research Interests:
Our research focuses on developmental cardiovascular biology. We are presently investigating cellular and molecular adaptations of the fetal heart to increased work load. This work is performed primarily in the fetal sheep and involves a number of surgical and benchtop investigations. We are also very interested in the field of "fetal programming", the concept that the intrauterine environment plays a powerful role in determining risks for adult onset diseases, such as hypertension, coronary artery disease and diabetes. We are taking a multidisciplinary approach to investigate mechanisms of hypertension and coronary artery dysfunction.
Research Team/Lab Members:
Thomas D. Scholz, MD
Professor of Pediatrics
Division of Pediatric Cardiology
Fred Lamb, MD, PhD
Associate Professor of Pediatrics
Division of Critical Care
Robert D. Roghair, MD
Fellow, Department of Pediatrics
Division of Neonatology
Ben Reinking, MD
Fellow, Department of Pediatrics
Division of Pediatric Cardiology
Aaron Olson, MD
Fellow, Department of Pediatrics
Division of Pediatric Cardiology
Kurt Bedell
Research Assistant
Department of Pediatric
Research Affiliations:
Department of Pediatrics, Division of Neonatology
Department of Pediatrics, Division of Pediatric Cardiology
Department of Pediatrics, Division of Critical Care
Department of Internal Medicine, Division of Cardiology
Department of Anatomy & Cell Biology
Model System:
Fetal and newborn sheep
Molecular and cell biology
Myocyte culture
Recent Publications:
- Hammel JM, Caldarone CA, Van Natta TL, Wang LX, Welke KF, Li W, Niles S, Barner E, Scholz TD, Behrendt DM, Segar JL.Myocardial apoptosis after cardioplegic arrest in the neonatal lamb.J Thorac Cardiovasc Surg. 2003;125:1268-75.
- Roghair RD, Lamb FS, Bedell KA, Smith OM, Scholz TD, Segar JL. Late-gestation betamethasone enhances coronary artery responsiveness to angiotensin II in fetal sheep. Am J Physiol. 2004;286:R80-8.
- Karimi M, Wang LX, Hammel JM, Mascio CE, Abdulhamid M, Barner EW, Scholz TD, Segar JL, Li WG, Niles SD, Caldarone CA. Neonatal vulnerability to ischemia and reperfusion: Cardioplegic arrest causes greater myocardial apoptosis in neonatal lambs than in mature lambs. J Thorac Cardiovasc Surg. 2004;127:490-7.
- Roghair RD, Lamb FS, Miller Jr FJ, Scholz TD, Segar JL. Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. Am J Physiol Regul Integr Comp Physiol. 2005;288(1):R46-53.
- Ralphe JC, Segar JL, Schutte BC, Scholz TD. Localization and function of the brain excitatory amino acid transporter type 1 in cardiac mitochondria. J Mol Cell Cardiol. 2004;37:33-41.
- Caldarone CA, Barner EW, Wang L, Karimi M, Mascio CE, Hammel JM, Segar JL, Du C, Scholz TD. Apoptosis-related mitochondrial dysfunction in the early postoperative neonatal lamb heart. Ann Thorac Surg. 2004;78:948-55.
- Van Natta TL, Ralphe JC, Mascio CE, Bedell KA, Scholz TD, Segar JL. Ontogeny of vascular growth factors in perinatal sheep myocardium. J Soc Gynecol Investig. 2004;11:503-10.
- Lumbers ER. Boyce AC. Joulianos G. Kumarasamy V. Barner E. Segar JL. Burrell JH. Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep. Am J Physiol 2005;288(3):R567-74.
- Roghair RD. Lamb FS. Miller FJ Jr. Scholz TD. Segar JL. Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. Am J Phys 2005;288:R46-53.
- Ralphe JC, Nau PN, Mascio CE, Segar JL, Scholz TD. Regulation of myocardial glucose transporters GLUT1 and GLUT4 in chronically anemic fetal lambs. Pediatr Res 2005;58:713-18.
- Mascio CE, Olson AK, Ralphe JC, Tomanek RJ, Scholz TD, Segar JL. Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep. Am J Physiol, 2005;289:R1736-45.
- Roghair RD, Segar JL, Sharma RV, Zimmerman MC, Jagadeesha DK, Segar EM, Scholz TD, Lamb FS. Newborn lamb coronary artery reactivity is programmed by early gestation dexamethasone before the onset of systemic hypertension. Am J Physiol 2005;289:R1169-76.
- Olson AK, Protheroe KN, Scholz TD, Segar JL. The mitogen-activated protein kinases and Akt are developmentally regulated in the chronically anemic fetal sheep heart. J Soc Gynecol Invest; 2006; in press.
- Olson AK, Protheroe KN, Segar JL, Scholz TD. Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart. Am J Physiol Heart Circ Physiol. 2006;90:H1587-95.
- Segar JL, Roghair RD, Segar EM, Scholz TD, Lamb FS. Early gestation dexamethasone alters baroreflex and vascular responses in newborn lambs prior to hypertension. Am J Physiol Regul Integr Comp Physiol; 2006; in press.
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