Aliye Uc, MD

Special Interests:
All gastrointestinal and liver disorders of childhood, with special interest in gastrointestinal motility disorders and functional gastrointestinal disorders

Research Interests:

• Regulation of heme uptake and transport in the intestines
• Role of heme degrading enzyme, heme oxygenase-1 (HO-1) in intestinal heme uptake and transport
• Role of HO-1 in the regulation of intestinal inflammation and cell proliferation

Recent Publications

Uc, A, Murray J.A., Kooy N, Conklin J.L. Effect of peroxynitrite on motor function of the opossum esophagus. Digestive Diseases and Sciences 46(1):30-37, 2001.

Uc, A, Chong SKF. Treatment of Helicobacter pylori gastritis improves dyspeptic symptoms in children. Journal of Pediatric Gastroenterology & Nutrition 34:281-285, 2002.

Uc, A. Is there another role for nitric oxide? Journal of Pediatric Gastroenterology & Nutrition 36:156, 2003.

Uc, A, Britigan B.E. Does heme oxygenase-1 have a role in Caco-2 cell cycle progression? Experimental Biology & Medicine. 228(5):590-5, 2003.

Uc, A, Kooy, NW, Conklin JL, Bishop W. Peroxynitrite inhibits epidermal growth factor receptor signaling in Caco-2 cells. Digestive Diseases and Sciences 48 (12):2353-2359, 2003.

Pashankar, DS, Uc, A, Bishop, WP. Polyethylene glycol 3350 without electrolytes: a new safe, effective, and palatable bowel preparation for colonoscopy in children. Journal of Pediatrics 144(3):358-62, 2004.

Uc, A, Stokes, JS, Britigan BE. Heme transport exhibits polarity in Caco-2 cells: Evidence for an active and membrane protein-mediated process. American Journal of Physiology 287(6):G1150-7, 2004.

Uc, A. Is recurrent abdominal pain a psychosomatic disorder? Journal of Pediatric Gastroenterology & Nutrition 39(5):571-2, 2004.

Uc, A, Husted, RF, Giriyappa, LG, Britigan, BE Stokes, JS. Hemin induces active chloride secretion in Caco-2 cells. American Journal of Physiology 289(2):G202-8, 2005.

Uc, A, Hyman, PE, Walker, LS. Functional gastrointestinal disorders in African-American children in primary care. Journal of Pediatric Gastroenterology & Nutrition 42(3):270-4, 2006.

Uc, A, Reszka KJ, Buettner GR, Stokes JB. Tin protoporphyrin induces intestinal chloride secretion by inducing light-oxidation processes. American Journal of Physiology, Cell Physiology 292:C1906-C1914, 2007.

E-mail: aliye-uc@uiowa.edu

Research Profile