Aliye Uc, MD
Research Profile

Our lab studies the regulatory mechanisms involved in the intestinal heme (the major source of nutritional iron) absorption and the role of heme degrading enzyme, heme oxygenase-1 (HO-1) in this process. We also study the role of HO-1 in the regulation of intestinal inflammation and cell proliferation. We employ confocal microscopy, ELISA assays of cytokine production, immunoblotting, RT-PCR and real-time RT-PCR, molecular cloning, flow cytometry, and assays to measure cellular redox state.

Lab Members:
Xiaoyan Zhu (RAIII)
Chun-Shu Wong (undergraduate student)

Affiliations:
Department of Pediatrics, Division of Pediatric Gastroenterology
Department of Radiation Oncology

Aliye Uc, MD lab

Left to right: Xiaoyan Zhu (RAIII), Chun-Shu Wong (undergraduate student), Aliye Uc

Model System:
Intestinal epithelial cell lines
Mice models of intestinal inflammation

Recent Publications

Uc, A, Britigan B.E. Does heme oxygenase-1 have a role in Caco-2 cell cycle progression? Experimental Biology & Medicine. 228(5):590-5, 2003.

Uc, A, Kooy, NW, Conklin JL, Bishop W. Peroxynitrite inhibits epidermal growth factor receptor signaling in Caco-2 cells. Digestive Diseases and Sciences 48 (12):2353-2359, 2003.

Uc, A, Stokes, JS, Britigan BE. Heme transport exhibits polarity in Caco-2 cells: Evidence for an active and membrane protein-mediated process. American Journal of Physiology 287(6):G1150-7, 2004.

Uc, A, Husted, RF, Giriyappa, LG, Britigan, BE Stokes, JS. Hemin induces active chloride secretion in Caco-2 cells. American Journal of Physiology 289(2):G202-8, 2005.

Uc, A, Reszka KJ, Buettner GR, Stokes JB. Tin protoporphyrin induces intestinal chloride secretion by inducing light-oxidation processes. American Journal of Physiology, Cell Physiology 292:C1906-C1914, 2007.

E-mail: aliye-uc@uiowa.edu

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