Aliye Uc, MD
Research Profile

Our lab studies the mechanisms involved in the regulatory and protective roles of heme oxygenase-1 (HO-1) against gut inflammation and oxidative stress. We also study the mechanisms of gastrointestinal involvement in cystic fibrosis using a novel CFTR-/- pig model. We employ upper GI endoscopy and endoscopic pancreatic function tests, light and confocal microscopy, ELISA assays of cytokine production, immunoblotting, RT-PCR and real-time RT-PCR, and assays to measure cellular redox state.

Lab Members
Xiaoyan Zhu (RAIII)
Radhamma Giriyappa (RAII)
Yi Zhao (volunteer)

Affiliations
Department of Pediatrics, Division of Pediatric Gastroenterology
Department of Radiation Oncology

Model System
Gastrointestinal epithelial cell lines
Mice models of gut inflammation
Pig model of cystic fibrosis

Aliye Uc, MD lab

From left to right: Xiaoyan Zhu, Aliye Uc, Radhamma Giriyappa

 

Recent Publications

Uc A, Britigan B.E. Does heme oxygenase-1 have a role in Caco-2 cell cycle progression? Experimental Biology & Medicine. 228(5):590-5, 2003.

Uc A, Kooy NW, Conklin JL, Bishop W. Peroxynitrite inhibits epidermal growth factor receptor signaling in Caco-2 cells. Digestive Diseases and Sciences 48 (12):2353-2359, 2003.

Uc A, Stokes JS, Britigan BE. Heme transport exhibits polarity in Caco-2 cells: Evidence for an active and membrane protein-mediated process. American Journal of Physiology 287(6):G1150-7, 2004.

Uc A, Husted RF, Giriyappa LG, Britigan BE, Stokes, JS. Hemin induces active chloride secretion in Caco-2 cells. American Journal of Physiology 289(2):G202-8, 2005.

Uc A, Reszka KJ, Buettner GR, Stokes JB. Tin protoporphyrin induces intestinal chloride secretion by inducing light-oxidation processes. American Journal of Physiology, Cell Physiology 292:C1906-C1914, 2007

Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ, Rogan MP, Pezzulo AA, Karp PH, Itani OA, Kabel AC, Wohlford-Lenane CL, Davis GJ, Smith TL, Samuel M, Wax D, Murphy CN, Rieke A, Whitworth K, Uc A, Starner TD, Brogden KA, Shilyansky J, McCray PB, Zabner J, Prather RS and Welsh MJ. Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Piglets. Accepted by Science.

E-mail: aliye-uc@uiowa.edu

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