Criteria for Participation
The purpose of this study is to determine whether bodily stores of essential fatty acids influence response to antidepressants and whether omega-3 fatty acid supplementation, when taken with antidepressant medication escitalopram (Lexapro), helps to improve depressive symptoms in individuals who have major depressive disorder (MDD). Omega-3 fatty acids are found in foods including walnuts, some fruits and vegetables, and coldwater fish such as herring, mackerel, sturgeon, and anchovies.

We are inviting you to participate in this research study if you have been diagnosed with MDD and you have not taken any antidepressant medication in the past month.

This research could lead to a better treatment for Major Depressive Disorder. Please look over this information.

Inclusion Criteria:

• Aged 18-55 years
• Current diagnosis of Major Depressive Disorder
• Not currently on antidepressants or on a stable dose

Exclusion Criteria:

• Substance dependence in the past year; substance abuse within the past month
• Presence of an eating disorder
• Allergy to fish
• Bleeding disorder/taking warfarin
• Omega-3 supplements for 3 or more days in the past 4 month period
• Known to be pregnant
• Taking medications known to produce depressive symptoms

Criteria for a Major Depressive Episode
Presences of five (or more) of the following symptoms during the same 2-week period and which present a change from previous functioning.

• Depressed mood (sad or empty) most of the day, nearly every day
• Markedly diminished interest or pleasure in all/almost all activities most of the day, nearly every day
• Decrease/increase in appetite; unintentional weight loss/gain
• Insomnia/sleeping more than usual
• Restlessness/physical agitation or slowed mental and physical pace observable by others
• Fatigue or loss of energy
• Feelings of worthlessness or guilt

If you would like to participate, please call 1-888-850-8531.