PACEMAKER: Winter 2005-06
Open Trials for Patients
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Heart attack and stroke
People ages 45 to 75 who are at high risk for a heart
attack or stroke are invited to participate in a University
of Iowa study designed to prevent these life-threatening
events. The study will evaluate whether use of an
investigational medication to raise HDL (good) cholesterol
will prevent heart attacks and strokes when combined with an
approved medication to lower LDL (bad) cholesterol. Eligible
participants may qualify for the study if they have had any
of the following: heart attack, chest pain, heart-related
surgery, stroke, or diabetes. The study will last five years
and involve approximately 17 to 20 visits to UI Hospitals
and Clinics over that time. Eligible participants randomly
will be assigned to take the two-medication combination or
only the medication for lowering LDL cholesterol. The
medication(s) will be provided at no cost. The study visits
will involve, also at no cost to participants, physical
exams, electrocardiograms, and blood and laboratory
evaluations. Compensation for travel and parking is
available. Approximately 200 people will take part in the UI
portion of the international study.
- UI STUDY LEAD: Jennifer Robinson, M.D.
- CONTACT: UI Lipid Research Center, 800-887-6917 or
319-384-5048
Memory tracking
Do you suffer from memory problems? Are you 65 years or
older? You might be eligible for a research project at the
University of Iowa that is tracking memory problems in older
adults.
- UI STUDY LEAD: Kevin Duff, Ph.D.
- CONTACT: Sara Van Der Heiden, 319-353-5336.
Urinary frequency and painful bladder
Men and women age 18 and older with certain urinary
frequency and bladder problems are invited to participate in
a University of Iowa Health Care research study on
interstitial cystitis and painful bladder syndrome. The
study will compare the safety and effectiveness of an
investigational medication to placebo (inactive substance)
in reducing symptoms. Interstitial cystitis is a chronic,
painful inflammatory condition of the bladder wall. People
with increased daytime and nighttime urinary frequency who
have never sought treatment are eligible to participate.
Individuals also eligible to participate are people who have
not yet received treatment for lower abdominal or pelvic
pain associated with a full bladder but who do not have a
urinary tract infection. The study will involve
approximately five visits to UI Hospitals and Clinics over
12 to 14 weeks. The study medication(s) and any blood or
urine tests will be provided at no cost. The study is funded
by the National Institute of Diabetes and Digestive and
Kidney Diseases of the National Institutes of Health.
- LEAD INVESTIGATOR: Karl Kreder, M.D.
- CONTACT: Call toll-free 866-309-0834 or 319-384-9265,
or e-mail mary-eno@uiowa.edu
Atherosclerotic renal artery stenosis
People with atherosclerotic renal artery stenosis
(narrowing of the kidney arteries), accompanied by high
blood pressure, are invited to participate in a national
study sponsored by the National Institutes of Health. During
the Cardiovascular Outcomes in Renal Atherosclerotic Lesions
(CORAL) study, participants will be randomized to one of two
groups: those who will receive medication alone to control
blood pressure and other risk factors, and those who will be
treated with medication and placement of a stent in the
blocked kidney artery. Participants will be followed for the
duration of the six-year study to determine which treatment
reduces incidences of heart attack, heart failure, stroke
and kidney failure. Historically, medication has been used
to control high blood pressure and associated problems. With
advances in technology, balloon angioplasty and
stents&endash;treatments used to open a blocked
artery&endash;have been used increasingly, without evidence
that they reduce the risk of heart and kidney problems. The
CORAL study will examine whether inserting a stent, or metal
scaffold, to keep the artery open will lead to better
outcomes overall for patients.
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