What is photodynamic therapy (PDT)?

PDT is a new way to destroy cancer cells using a drug that is activated by being exposed to light. Depending on where the cancer is located, we either treat internally or superficially. After the cancer cells absorb the drug, a light source is applied to the area being treated. This causes the drug to react with oxygen, which forms a chemical that kills the cancer cells.

Who might benefit the most from PDT?

PDT can be as effective as surgery or radiation therapy in treating certain kinds of cancers and precancerous conditions. Most notably it is a new and promising alternative for patients who are not candidates for surgical removal of tumors in the lungs and esophagus.

What are the advantages?

• Can be repeated several times at the same site, if necessary
• Less invasive than surgery
• Less scarring
• Very precise targeting of cancer cells

What about limitations?

While PDT is not widely used to treat cancer at this time, it is mainly limited to the treatment of areas on or just under the skin, or in the lining of internal organs.

What distinguishes the PDT program at UI Hospitals and Clinics?

We are the only medical center in Iowa to offer the procedure. Previously, many patients went out-of-state for treatment. We have treated several patients to date, with good results.

Mark Iannettoni, MD