Because of the increased risk for breast cancer, women should have increased breast cancer surveillance. This includes performing monthly breast self-examination and having a clinical breast examination every six to 12 months beginning at age 21. Beginning at 30 to 35 years of age, annual mammograms are recommended. Some young women have dense breast tissue that can limit the detection of early breast cancer associated with PTEN gene changes. Prophylactic mastectomy is an option available to women for whom screening is not effective or who have had multiple breast biopsies. Men also have an increased risk for breast cancer and because of this should perform a monthly breast self-exam beginning at age 21 years. Women should also receive annual endometrial cancer screening beginning at age 30 to 35 years.Both men and women should receive annual thyroid cancer surveillance that includes a baseline ultrasound of the thyroid during adolescence. After the baseline is complete, annual thyroid palpation to identify changes is recommended. Because thyroid nodules can be a common feature, experienced endocrinologists need to evaluate any thyroid nodules to determine if they require additional follow-up, such as a biopsy.Skin and colon cancer screenings should also be done annually. Please see the surveillance guidelines section within the pamphlet for colon screening recommendations pertaining to JP.

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