Hereditary Diseases and Cancer: Cancer Prevention: Cancer Center: UI Health Topics

Cancer Prevention: What You Need To Know

Hereditary Diseases and Cancer

Peer Review Status: Internally Reviewed by Cancer Center Staff
Creation Date: 1996
Last Revision Date: April 2001

* Definition of Terms

Cancer Site	Hereditary Risk Factors
Adrenal Gland Cancer	Familial Adenomatous Polyposis (FAP) Li-Fraumeni Syndrome Multiple Endocrine Neoplasia I and II Neurofibromatosis von Hippel-Lindau Syndrome
Anal Cancer	Fanconi Anemia
Bile Duct Cancer	Familial Adenomatous Polyposis (FAP) Lynch II Syndrome Werner Syndrome
Bladder Cancer	Lynch II Syndrome
Bone Cancer	Familial Adenomatous Polyposis (FAP) Li-Fraumeni Syndrome Retinoblastoma Gene Werner Syndrome
Brain Cancer	Ataxia Telangiectasia Basal Cell Nevus Syndrome (Childhood Medulloblastoma) BRCA 1 possibly Fanconi Anemia Li-Fraumeni Syndrome Lynch II Syndrome Neurofibromatosis Retinoblastoma Gene Tuberous Sclerosis (Childhood Brain Tumor) Turcot Syndrome von Hippel-Lindau Syndrome Xeroderma Pigmentosum
Breast Cancer	Ataxia Telangiectasia Bloom Syndrome BRCA1 Gene Mutations BRCA2 Gene Mutations (Females and Males) Cowden Syndrome Li-Fraumeni Syndrome Peutz-Jeghers Syndrome Werner Syndrome
Central Nervous System	Familial Adenomatous Polyposis (FAP) Neurofibromatosis
Cervical Cancer	Bloom Syndrome Fanconi Anemia Peutz-Jeghers Syndrome
Colorectal Cancer	Agammaglobulinemia Bloom Syndrome BRCA 1 possibly BRCA 2 Familial Adenomatous Polyposis (FAP) Familial Non-Medullary Thyroid Cancer (FNMTC) Lynch I Syndrome Lynch II Syndrome Muir-Torre Syndrome Peutz-Jeghers Syndrome Turcot Syndrome
Esophagus	Bloom Syndrome Fanconi Anemia
Eye Cancer	Neurofibromatosis Retinoblastoma Gene Xeroderma Pigmentosum
Head and neck	Fanconi Anemia
Hypothalamus	Neurofibromatosis
Gastric (Stomach) Cancer	Ataxia Telangiectasia Familial Adenomatous Polyposis (FAP) possibly Li-Fraumeni Syndrome Lynch II Syndrome Turcot Syndrome Werner Syndrome Xeroderma Pigmentosum
Kidney Cancer	Cowden Syndrome Neurofibromatosis Tuberous Sclerosis von Hippel-Lindau Syndrome Wilms Tumor Gene
Larynx Cancer	Bloom Syndrome possibly Li Fraumeni Syndrome Muir-Torre Syndrome
Leukemia	Ataxia-Telangiectasia Bloom Syndrome Fanconi Anemia Li-Fraumeni Syndrome Neurofibromatosis (childhood Leukemia) Retinoblastoma Gene Werner Syndrome Xeroderma Pigmentosum
Liver Cancer	Familial Adenomatous Polyposis (FAP) Fanconi Anemia Werner Syndrome
Lung Cancer	Bloom Syndrome BRCA 1 Li-Fraumeni Syndrome Multiple Endocrine Neoplasia I (Bronchial Carcinoma and Carcinoid) Wilms Tumor Gene (Mesothelioma: May also occur in abdomen) Xeroderma Pigmentosum
Lymphoma	Ataxia Telangiectasia Bloom Syndrome Li-Fraumeni Syndrome Retinoblastoma Gene
Ovarian Cancer	Basal Cell Nevus Syndrome BRCA1 Lynch II Syndrome Multiple Endocrine Neoplasia I Peutz-Jeghers Syndrome
Ovarian Germ Cell Tumor	Li-Fraumeni Syndrome
Pancreatic Cancer	BRCA 1 BRCA 2 Familial Melanoma Syndrome Li-Fraumeni Syndrome Lynch II Syndrome Multiple Endocrine Neoplasia I Peutz-Jeghers Syndrome von Hippel-Lindau Syndrome
Parathyroid Cancer	Multiple Endocrine Neoplasia I & II Neurofibromatosis
Pituitary Gland	Multiple Endocrine Neoplasia I
Prostate Cancer	BRCA1 Possibly BRCA 2 Hereditary Prostate Cancer 1 (HPC1) Li-Fraumeni Syndrome
Skin Cancer
Melanoma	BRCA 1 Familial Melanoma Syndrome Li-Fraumeni Syndrome Retinoblastoma Gene Werner Syndrome Xeroderma Pigmentosum
Non-melanoma skin cancer	Ataxia Telangiectasia Basal Cell Nevus Syndrome Bloom Syndrome Lynch II Syndrome Muir-Torre Syndrome Turcot Syndrome (Scalp) Xeroderma Pigmentosum
Merkel Cell Skin Cancer	Cowden Syndrome
Small Intestine	Familial Adenomatous Polyposis (FAP) (Duodenum) Lynch II Syndrome Muir-Torre Syndrome (Duodenum) Multiple Endocrine Neoplasia I (Duodenum) Neurofibromatosis (Duodenum) Peutz-Jeghers Syndrome (Duodenum)
Soft Tissue Sarcoma	BRCA 1 Li-Fraumeni Syndrome Multiple Endocrine Neoplasia I Neurofibromatosis Retinoblastoma Gene Werner Syndrome
Spinal Cord	Neurofibromatosis von Hippel-Lindau Syndrome
Testicular Cancer	Peutz-Jeghers Syndrome
Testes Germ Cell Tumors	Li-Fraumeni Syndrome
Thymus	Multiple Endocrine Neoplasia I
Thyroid	Cowden Syndrome Familial Adenomatous Polyposis (FAP) Familial Non-Medullary Thyroid Cancer (FNMTC) (Papillary) Multiple Endocrine Neoplasia II (Medullary) Werner Syndrome
Tongue	Bloom Syndrome Xeroderma Pigmentosum
Urologic Systems Cancer	Lynch II Syndrome
Uterine Cancer	Ataxia Telangiectasia Lynch II Syndrome
Vulva	Fanconi Anemia

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