The beta-2 agonists are best delivered by aerosol – these are much more effective and more free of annoying side effects that the oral agents in this class. While popularly used in the past as solutions in compressed air driven nebulae's, the use of valved holding chambers has been shown to be as effective when up to 6 inhalations of albuterol are used (which is still a lower dose than conventional nebulizer doses). The valved holding chamber (don’t call them spacers) eliminate the need for precise coordination of inspiration with actuation. Used with a soft flexible face mask, they can even be used for the youngest patients.

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